Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.[5]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]
MAPK1 has been shown to interact with:
Mutations in MAPK1 are implicated in many types of cancer.[45]
MAP kinase activation
| |
---|---|
Initiation |
|
MAP kinase kinase kinase (MAP3K or MKKK) |
|
MAP kinase kinase (MAP2K or MKK) |
|
MAP kinase |
|
Phosphatase |
|
PDB gallery
| |
---|---|
1erk: STRUCTURE OF SIGNAL-REGULATED KINASE
1gol: COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
1pme: STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
1tvo: The structure of ERK2 in complex with a small molecule inhibitor
1wzy: Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
2erk: PHOSPHORYLATED MAP KINASE ERK2
2fys: Crystal structure of Erk2 complex with KIM peptide derived from MKP3
2gph: Docking motif interactions in the MAP kinase ERK2
2ojg: Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2oji: Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2ojj: Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
3erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
4erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE
|
| |||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||
|
| |
---|---|
Activity |
|
Regulation |
|
Classification |
|
Kinetics |
|
Types |
|