EFNA2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | EFNA2, ELF-1, EPLG6, HEK7-L, LERK-6, LERK6, ephrin A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602756; MGI: 102707; HomoloGene: 1075; GeneCards: EFNA2; OMA:EFNA2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.[5]
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[5]
Intercellular signaling peptides and proteins / ligands
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Growth factors |
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Ephrin |
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Other |
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see also extracellular ligand disorders |
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