Contents

HOXB2

Protein-coding gene in humans

HOXB2
Identifiers
Aliases	HOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDs	OMIM: 142967; MGI: 96183; HomoloGene: 37584; GeneCards: HOXB2; OMA:HOXB2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,540,894 bp[1] End 48,545,109 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.85 cM Start 96,241,351 bp[2] End 96,244,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula right uterine tube corpus epididymis muscle layer of sigmoid colon caput epididymis left coronary artery gastric mucosa Descending thoracic aorta right coronary artery canal of the cervix Top expressed in embryo somite tail of embryo transitional epithelium of urinary bladder seminal vesicula proximal tubule adrenal gland right kidney enteric nervous system medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm cytosol nuclear speck Biological process multicellular organism development regulation of transcription, DNA-templated blood circulation transcription, DNA-templated morphogenesis of an epithelial sheet anterior/posterior pattern specification dorsal/ventral pattern formation rhombomere 3 development rhombomere 4 development facial nerve structural organization embryonic skeletal system morphogenesis skeletal system morphogenesis neural nucleus development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3212 103889 Ensembl ENSG00000173917 ENSMUSG00000075588 UniProt P14652 P0C1T1 RefSeq (mRNA) NM_002145 NM_134032 RefSeq (protein) NP_002136 NP_598793 Location (UCSC) Chr 17: 48.54 – 48.55 Mb Chr 11: 96.24 – 96.24 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.^[5][6][7]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.^[7]

See also[edit]

• Homeobox

References[edit]

Further reading[edit]

External links[edit]

• HOXB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.