DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.[5]
The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.[6] The ID2 protein may play a role in the development and resistance to therapies of glioblastoma, the most aggressive of brain cancers.[7]
ID2 has been shown to interact with MyoD[8] and NEDD9.[9]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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