Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[5][6]
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[6]
NEUROD2 has been shown to interact with Protein kinase N1.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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