Contents

HR (gene)

Protein-coding gene in the species Homo sapiens

HR
Identifiers
Aliases	HR, ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1, hair growth associated, lysine demethylase and nuclear receptor corepressor, HR lysine demethylase and nuclear receptor corepressor
External IDs	OMIM: 602302; MGI: 96223; HomoloGene: 3774; GeneCards: HR; OMA:HR - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,114,419 bp[1] End 22,133,384 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,789,652 bp[2] End 70,810,988 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg right hemisphere of cerebellum mucosa of transverse colon vulva right frontal lobe nipple sural nerve prefrontal cortex parotid gland Top expressed in lip hair bulb muscle of thigh Epithelium of large intestine inner root sheath esophagus triceps brachii muscle epithelium of rectum skin of back Inner enamel epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding oxidoreductase activity transcription corepressor activity metal ion binding transcription cis-regulatory region binding chromatin DNA binding histone H3-methyl-lysine-9 demethylase activity Cellular component nuclear body nucleoplasm chromatin nucleus Biological process negative regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated histone H3-K9 demethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55806 15460 Ensembl ENSG00000168453 ENSMUSG00000022096 UniProt O43593 Q61645 RefSeq (mRNA) NM_005144 NM_018411 NM_021877 NM_001379479 RefSeq (protein) NP_005135 NP_060881 NP_068677 NP_001366408 Location (UCSC) Chr 8: 22.11 – 22.13 Mb Chr 14: 70.79 – 70.81 Mb PubMed search [3] [4]
Wikidata
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HR is a gene encoding Protein hairless.^[5][6][7]

This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases.^[7]

Human Genetics[edit]

Variations in this gene are involved in low levels of hair (baldness / alopecia / hypotrichosis)^[8] Mutations in this gene in humans have been documented in cases of autosomal recessive congenital alopecia^[9] and atrichia with papular lesions.^{[10][11] [12] [13] [14]}

The protein contains a Zinc finger domain.^[12][10]

See also[edit]

• Corepressor

References[edit]

Further reading[edit]

External links[edit]

• HR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)