Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.[5][6]
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.[7]
SIN3A has been shown to interact with:
PDB gallery
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1g1e: NMR STRUCTURE OF THE HUMAN MAD1 TRANSREPRESSION DOMAIN SID IN COMPLEX WITH MAMMALIAN SIN3A PAH2 DOMAIN
1s5q: Solution Structure of Mad1 SID-mSin3A PAH2 Complex
1s5r: Solution Structure of HBP1 SID-mSin3A PAH2 Complex
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Coactivators |
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Corepressors |
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ATP-dependent remodeling factors |
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.