| Alpha trans-inducing protein (Alpha-TIF) | |||||||||||
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Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.[1]
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| Identifiers | |||||||||||
| Symbol | Alpha_TIF | ||||||||||
| Pfam | PF02232 | ||||||||||
| InterPro | IPR003174 | ||||||||||
| SMART | SM00814 | ||||||||||
| SCOP2 | 16vp / SCOPe / SUPFAM | ||||||||||
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Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.[3][4]
VP16 is a strong transactivator[5] and is often used in Y2H systems as the activation domain of the system.[6]
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| DNA |
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| RNA |
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| RT |
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