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Mofebutazone

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Mofebutazone
Clinical data

ATC code	M01AA02 (WHO) M02AA02 (WHO)
Identifiers
IUPAC name 4-butyl-1-phenylpyrazolidine-3,5-dione
CAS Number	2210-63-1^Y
PubChem CID	16639
ChemSpider	15776^N
UNII	SPW36WUI5Z
KEGG	D07262^Y
ChEBI	CHEBI:76252^N
CompTox Dashboard (EPA)	DTXSID4023331
ECHA InfoCard	100.016.947
Chemical and physical data
Formula	C₁₃H₁₆N₂O₂
Molar mass	232.283 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCCC1C(=O)NN(C1=O)c2ccccc2
InChI InChI=1S/C13H16N2O2/c1-2-3-9-11-12(16)14-15(13(11)17)10-7-5-4-6-8-10/h4-8,11H,2-3,9H2,1H3,(H,14,16)^N Key:REOJLIXKJWXUGB-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Mofebutazone (ormonophenylbutazone) is a drug used for joint and muscular pain.^[1]^[2] It is a 3,5-pyrazolinedione derivative.

The drug binds to plasma albumin and competes with drugs such as coumarin anticoagulants, indomethacin and glucocorticoids.

References[edit]

^ Kassem MA, Schulte KE (1984-07-01). "Pharmacokinetics of [4-14C] mofebutazone after oral administration in man". European Journal of Drug Metabolism and Pharmacokinetics. 9 (3): 223–227. doi:10.1007/BF03189645. PMID 6519123. S2CID 10985688.

^ Paradies HH (December 1987). "Structure of phenylbutazone and mofebutazone in the crystalline state and in solution". Journal of Pharmaceutical Sciences. 76 (12): 920–929. doi:10.1002/jps.2600761217. PMID 3440938.

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
category commons portal

Topical products for joint and muscular pain (M02)

Anti-inflammatory
preparations,
non-steroids

Pyrazolidines

Acetic acid
derivatives

Other

Capsaicin derivatives

Zucapsaicin

Other

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Mofebutazone&oldid=1148912998" Categories: ●Nonsteroidal anti-inflammatory drugs ●Pyrazolidindiones ●Musculoskeletal system drug stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●Articles with changed ChemSpider identifier ●Articles with changed EBI identifier ●ECHA InfoCard ID from Wikidata ●Articles with changed InChI identifier ●Chemical pages without DrugBank identifier ●Drugs with no legal status ●Drugboxes which contain changes to verified fields ●Drugboxes which contain changes to watched fields ●All stub articles ●This page was last edited on 9 April 2023, at 01:38 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view