Combination of | |
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Naproxen | NSAID |
Diphenhydramine | Antihistamine |
Clinical data | |
Trade names | Aleve PM |
AHFS/Drugs.com | aleve-pm |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status |
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Naproxen/diphenhydramine (trade name Aleve PM) is a formulation of naproxen with diphenhydramine marketed by Bayer Healthcare.[1] It is made as an over-the-counter drug. The intended use of the drug is relieve pain specifically when going to sleep.[2]
Women in the third trimester of pregnancy should avoid this drug because there is a risk that naproxen, like other NSAIDs, may cause premature closure of the ductus arteriosus.[2]
In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[3][4] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[3][4]
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Diarylmethanes |
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Ethylenediamines |
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Tricyclics |
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Others |
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For topical use |
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pyrazolones / pyrazolidines |
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salicylates |
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acetic acid derivatives and related substances |
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oxicams |
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propionic acid derivatives (profens) |
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n-arylanthranilic acids (fenamates) |
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COX-2 inhibitors (coxibs) |
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other |
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NSAID combinations |
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
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