PTPN14 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603155; MGI: 102467; HomoloGene: 3941; GeneCards: PTPN14; OMA:PTPN14 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[5][6]
The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[6]
PTPN14 has been shown to interact with Beta-catenin.[7]
PDB gallery
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2bzl: CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1.65 A RESOLUTION
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