M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.[5]
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.[6]
CDC25B has been shown to interact with MAPK14,[7] Casein kinase 2, alpha 1,[8] CHEK1,[9] MELK,[10] Estrogen receptor alpha,[11] YWHAB,[12][13] YWHAZ,[12] YWHAH[12] and YWHAE.[12][13]
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PDB gallery
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1cwr: HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE
1cws: HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE
1cwt: HUMAN CDC25B CATALYTIC DOMAIN WITH METHYL MERCURY
1qb0: HUMAN CDC25B CATALYTIC DOMAIN
1ym9: Crystal structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfinic form
1ymd: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfonic form
1ymk: Crystal Structure of the CDC25B phosphatase catalytic domain in the apo form
1yml: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfenic form
1ys0: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the disulfide form
2a2k: Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain
2ifd: Crystal structure of a remote binding site mutant, R492L, of CDC25B Phosphatase catalytic domain
2ifv: Crystal structure of an active site mutant, C473D, of CDC25B phosphatase catalytic domain
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