PTPN18 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606587; MGI: 108410; HomoloGene: 74971; GeneCards: PTPN18; OMA:PTPN18 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.[5][6]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.[6]
PTPN18 has been shown to interact with PSTPIP1.[7]
PDB gallery
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2oc3: Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18
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