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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
1-phosphatidyl-1D -myo -inositol = 1D -myo -inositol 1,2-cyclic phosphate + 1,2-diacyl-sn -glycerol
This enzyme belongs to the family of lyases , specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D -myo -inositol 1,2-diacyl-sn -glycerol-lyase (1 D -myo -inositol-1,2-cyclic-phosphate-forming) . Other names in common use include monophosphatidylinositol phosphodiesterase , phosphatidylinositol phospholipase C , 1-phosphatidylinositol phosphodiesterase , 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase , (cyclic-phosphate-forming) , 1-phosphatidyl-1D -myo -inositol diacylglycerol-lyase , and (1,2-cyclic-phosphate-forming) . It participates in inositol phosphate metabolism .
Structural studies [ edit ]
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2 .
References [ edit ]
Allan D, Michell RH (1974). "Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0" . Biochem. J . 142 (3 ): 591–7. doi :10.1042/bj1420591 . PMC 1168323 . PMID 4377210 .
Friedel RO, Brown JD, Durell (1967). "Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain". Biochim. Biophys. Acta . 144 (3 ): 684–6. doi :10.1016/0005-2760(67 )90059-8 . PMID 4294905 .
Irvine RF (1982). "The enzymology of stimulated inositol lipid turnover". Cell Calcium . 3 (4–5): 295–309. doi :10.1016/0143-4160(82 )90018-5 . PMID 6297738 .
Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus )" . FEBS Lett . 53 (3 ): 302–4. doi :10.1016/0014-5793(75 )80041-X . PMID 236918 . S2CID 5813981 .
Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C" . Biochem. J . 167 (1 ): 281–4. doi :10.1042/bj1670281 . PMC 1183647 . PMID 588258 .
Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG (1988). "Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C" . Nucleic Acids Res . 16 (21 ): 10383. doi :10.1093/nar/16.21.10383 . PMC 338883 . PMID 3194218 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Phosphatidylinositol_diacylglycerol-lyase&oldid=1187164574 "
C a t e g o r i e s :
● E C 4 . 6 . 1
● E n z y m e s o f k n o w n s t r u c t u r e
● E n z y m e s t u b s
H i d d e n c a t e g o r y :
● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 7 N o v e m b e r 2 0 2 3 , a t 2 1 : 3 6 ( U T C ) .
● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n .
● P r i v a c y p o l i c y
● A b o u t W i k i p e d i a
● D i s c l a i m e r s
● C o n t a c t W i k i p e d i a
● C o d e o f C o n d u c t
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