Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.
NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]
It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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G protein-coupled receptor |
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Type I cytokine receptor |
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Enzyme-linked receptor |
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Other |
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Receptor protein serine/threonine kinase |
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Receptor tyrosine kinase |
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Guanylate cyclase-coupled receptor |
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Receptor tyrosine phosphatase |
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4.6.1 |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Types |
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