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● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
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Search
A p p e a r a n c e
● C r e a t e a c c o u n t ● L o g i n
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● C r e a t e a c c o u n t ● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 R e f e r e n c e s
T o g g l e t h e t a b l e o f c o n t e n t s
P h o s p h o k e t o l a s e
4 l a n g u a g e s
● G a l e g o ● 日 本 語 ● С р п с к и / s r p s k i ● S r p s k o h r v a t s k i / с р п с к о х р в а т с к и
E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
● R e a d ● E d i t ● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d ● E d i t ● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e ● R e l a t e d c h a n g e s ● U p l o a d f i l e ● S p e c i a l p a g e s ● P e r m a n e n t l i n k ● P a g e i n f o r m a t i o n ● C i t e t h i s p a g e ● G e t s h o r t e n e d U R L ● D o w n l o a d Q R c o d e ● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
D-xylulose 5-phosphate + phosphate
⇌
{\displaystyle \rightleftharpoons }
2 EC 4.1.2.9 ) [1]
D-fructose 6-phosphate + phosphate
⇌
{\displaystyle \rightleftharpoons }
2 EC 4.1.2.22 )[2]
D-sedoheptulose 7-phosphate + phosphate
⇌
{\displaystyle \rightleftharpoons }
2 O [3]
Phosphoketolase is considered a promiscuous enzyme because it was demonstrated to use 3 different sugar phosphates as substrates. In a recent genetic study, more than 150 putative phosphoketolase genes exhibiting varying catalytic properties were found in 650 analyzed bacterial genomes.[4]
This enzyme belongs to the family of lyases , specifically the aldehyde-lyases, which cleave carbon-carbon bonds. It participates in 3 metabolic pathways : pentose phosphate pathway , methane metabolism , and carbon fixation . It employs one cofactor , thiamin diphosphate . Phosphoketolase was previously used for biotechnological purposes[5] [6] [7] reducing power .[8]
References [ edit ]
^ Racker, E. (1962), [29d] Fructose-6-phosphate phosphoketolase from Acetobacter xylinum , Methods in Enzymology, vol. 5, Elsevier, pp. 276–280, doi :10.1016/s0076-6879(62 )05219-2 , ISBN 9780121818050
^ Krüsemann, Jan L.; Lindner, Steffen N.; Dempfle, Marian; Widmer, Julian; Arrivault, Stephanie; Debacker, Marine; He, Hai; Kubis, Armin; Chayot, Romain (2018). "Artificial pathway emergence in central metabolism from three recursive phosphoketolase reactions" . The FEBS Journal . 285 (23 ): 4367–4377. doi :10.1111/febs.14682 ISSN 1742-4658 . PMID 30347514 .
^ Sánchez, Borja; Zúñiga, Manuel; González-Candelas, Fernando; de los Reyes-Gavilán, Clara G.; Margolles, Abelardo (2010). "Bacterial and Eukaryotic Phosphoketolases: Phylogeny, Distribution and Evolution". Journal of Molecular Microbiology and Biotechnology . 18 1 ): 37–51. doi :10.1159/000274310 . ISSN 1464-1801 . PMID 20068356 .
^ Sonderegger, M.; Schumperli, M.; Sauer, U. (2004-05-01). "Metabolic Engineering of a Phosphoketolase Pathway for Pentose Catabolism in Saccharomyces cerevisiae" . Applied and Environmental Microbiology . 70 5 ): 2892–2897. Bibcode :2004ApEnM..70.2892S . doi :10.1128/aem.70.5.2892-2897.2004 . ISSN 0099-2240 . PMC 404438 PMID 15128548 .
^ Anfelt, Josefine; Kaczmarzyk, Danuta; Shabestary, Kiyan; Renberg, Björn; Rockberg, Johan; Nielsen, Jens; Uhlén, Mathias; Hudson, Elton P. (2015-10-16). "Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production" . Microbial Cell Factories . 14 1 ): 167. doi :10.1186/s12934-015-0355-9 ISSN 1475-2859 . PMC 4609045 PMID 26474754 .
^ Meadows, Adam L.; Hawkins, Kristy M.; Tsegaye, Yoseph; Antipov, Eugene; Kim, Youngnyun; Raetz, Lauren; Dahl, Robert H.; Tai, Anna; Mahatdejkul-Meadows, Tina (September 2016). "Rewriting yeast central carbon metabolism for industrial isoprenoid production". Nature . 537 (7622): 694–697. Bibcode :2016Natur.537..694M . doi :10.1038/nature19769 . ISSN 0028-0836 . PMID 27654918 .
^ Bogorad, Igor W.; Lin, Tzu-Shyang; Liao, James C. (2013-09-29). "Synthetic non-oxidative glycolysis enables complete carbon conservation". Nature . 502 (7473): 693–697. Bibcode :2013Natur.502..693B . doi :10.1038/nature12575 . ISSN 0028-0836 . PMID 24077099 .
t
e
Activity
Regulation
Classification
Kinetics
Types
t
e
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Phosphoketolase&oldid=1230330236 " C a t e g o r i e s : ● E C 4 . 1 . 2 ● T h i a m i n e e n z y m e s ● E n z y m e s o f u n k n o w n s t r u c t u r e ● E C 4 . 1 s t u b s H i d d e n c a t e g o r y : ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 2 J u n e 2 0 2 4 , a t 0 3 : 1 4 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O (EC 4.1.2.9) [1]
