Jaenisch’s first breakthrough occurred in 1974, when he and Beatrice Mintz showed that foreign DNA could be integrated into the DNA of early mouse embryos[5] They injected retrovirus DNA into early mouse embryos and showed that leukemia DNA sequences had integrated into the mouse genome and also into that of its offspring. These mice were the first transgenic mammals in history.[6]
His current research focuses on the epigenetic regulation of gene expression,[7] which has led to major advances in creating embryonic stem cells and “induced pluripotent stem" (IPS) cells, as well as their therapeutic applications. In 2007, Jaenisch’s laboratory was one of the first three laboratories worldwide to report reprogramming cells taken from a mouse's tail into IPS cells. Jaenisch has since shown therapeutic benefits of IPS cell-based treatment for sickle-cell anemia and Parkinson's disease in mice. Additional research focuses on the epigenetic mechanisms involved in cancer and brain development.[3]
Jaenisch’s therapeutic cloning research deals exclusively with mice, but he is an advocate for using the same techniques with human cells in order to advance embryonic stem cell research.[8] However, in 2001, Jaenisch made a public case against human reproductive cloning, testifying before a U.S. House of Representatives subcommittee[9] and writing an editorial in Science magazine.[10]
Jaenisch received his doctorate in medicine from the University of Munich in 1967, preferring the laboratory to the clinic. He became a postdoc at the Max Planck Institute in Munich, studying bacteriophages.[11] He left Germany in 1970 for research positions at Princeton University, Fox Chase Institute for Cancer Research and the Salk Institute. He returned to Germany in 1977 to become the head of the Department of Tumor Virology at the Heinrich Pette Institute at the University of Hamburg. He arrived at MIT in 1984.[12] He participated in the 2005 science conference on human cloning at the United Nations and serves on the science advisory boards of the Genetics Policy Institute[13] and Stemgent.[14] He also served on the Life Sciences jury for the Infosys Prize in 2010.
^Ferrone, Frank A. (2015). "2013 Benjamin Franklin Medal in Life Science presented to Rudolf Jaenisch". Journal of the Franklin Institute. 352 (7): 2587–2590. doi:10.1016/j.jfranklin.2015.03.004.
