Stanley Prusiner
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Prusiner in 2024
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| Born | Stanley Ben Prusiner (1942-05-28) May 28, 1942 (age 82)
Des Moines, Iowa, United States
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| Nationality | American |
| Alma mater | University of Pennsylvania (BA, MD) |
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| Spouse | Sandy Turk Prusiner[3] |
| Children | two[3] |
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| Website | ind |
Stanley Ben Prusiner (born May 28, 1942[3]) is an American neurologist and biochemist. He is the director of the Institute for Neurodegenerative Diseases at University of California, San Francisco (UCSF).[4] Prusiner discovered prions, a class of infectious self-reproducing pathogens primarily or solely composed of protein, a scientific theory considered by many as a heretical idea when first proposed. He received the Albert Lasker Award for Basic Medical Research in 1994 and the Nobel Prize in Physiology or Medicine in 1997 for research on prion diseases developed by him and his team of experts (David E. Garfin,[5] D. P. Stites, W. J. Hadlow, C. M. Eklund) beginning in the early 1970s.[6][7]
He was born in Des Moines, Iowa, into a Jewish[8] family to Miriam (Spigel) and Lawrence Prusiner, an architect. He spent his childhood in Des Moines and Cincinnati, Ohio, where he attended Walnut Hills High School, where he was known as "the little genius" for his groundbreaking work on a repellent for Boxelder bugs. Prusiner received a Bachelor of Arts degreeinchemistry from the University of Pennsylvania and later received his M.D. from the University of Pennsylvania School of Medicine.[3] Prusiner then completed an internship in medicine at the University of California, San Francisco. Later Prusiner moved to the National Institutes of Health, where he studied glutaminases in E. coli in the laboratory of Earl Stadtman.[citation needed]
After three years at NIH, Prusiner returned to UCSF to complete a residencyinneurology. Upon completion of the residency in 1974, Prusiner joined the faculty of the UCSF neurology department. Since that time, Prusiner has held various faculty and visiting faculty positions at both UCSF and UC Berkeley.[citation needed]
Since 1999, Prusiner has been director of the Institute for Neurodegenerative Diseases research laboratory at UCSF, working on prion diseases, Alzheimer's disease and tauopathies.[9]
In his 1998 PNAS review article on Prions, Prusiner wrote: "The idea that scrapie prions were composed of an amyloidogenic protein was truly heretical when it was introduced." Encephalopathy was a mysterious disease that attacks the brain, and leaves the brains of its victims full of holes. Scientists did not know what pathogen or disease-causing organism that produced such pattern. Prusiner and his co-workers suggested "One scientific theory, viewed as heretical in that it seems to challenge the role of nucleic acids as the exclusive carriers of genetic information." This theory suggested that this pathogen might be a "deadly variety of a normal protein that has the ability to amplify itself in the brain. The hypothetical protein is called a prion (pronounced PREE-on)."[10][11][12]
Stanley Prusiner was awarded the Nobel Prize in Physiology or Medicine in 1997 for his work in proposing an explanation for the cause of bovine spongiform encephalopathy ("mad cow disease") and its human equivalent, Creutzfeldt–Jakob disease.[3] In this work, he coined the term prion, which comes from the words "proteinaceous" and "infectious," in 1982 to refer to a previously undescribed form of infection due to protein misfolding.[13]
Prusiner was elected to the National Academy of Science in 1992 and to its governing council in 2007.[14] He is also an elected member of the American Academy of Arts and Sciences (1993),[15]aForeign Member of the Royal Society (ForMemRS) in 1997,[2][16] and the American Philosophical Society (1998),[17] the Serbian Academy of Sciences and Arts (2003), and the Institute of Medicine.
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1997 Nobel Prize laureates
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| Literature (1997) | Dario Fo (Italy) |
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| Physics |
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| Physiology or Medicine | Stanley B. Prusiner (United States) |
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