J u m p t o c o n t e n t
M a i n m e n u
M a i n m e n u
N a v i g a t i o n
● M a i n p a g e
● C o n t e n t s
● C u r r e n t e v e n t s
● R a n d o m a r t i c l e
● A b o u t W i k i p e d i a
● C o n t a c t u s
● D o n a t e
C o n t r i b u t e
● H e l p
● L e a r n t o e d i t
● C o m m u n i t y p o r t a l
● R e c e n t c h a n g e s
● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t
● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t
● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e
● C o n t r i b u t i o n s
● T a l k
( T o p )
1
E a r l y l i f e a n d e d u c a t i o n
2
C a r e e r
3
H o n o u r s a n d a w a r d s
4
P e r s o n a l l i f e
5
R e f e r e n c e s
6
E x t e r n a l l i n k s
T o g g l e t h e t a b l e o f c o n t e n t s
A r v i d C a r l s s o n
4 9 l a n g u a g e s
● ا ل ع ر ب ي ة
● A z ə r b a y c a n c a
● ت ۆ ر ک ج ه
● ব া ং ল া
● Б е л а р у с к а я
● Б ъ л г а р с к и
● C a t a l à
● Č e š t i n a
● D a n s k
● D e u t s c h
● E e s t i
● E s p a ñ o l
● E u s k a r a
● ف ا ر س ی
● F r a n ç a i s
● G a e i l g e
● G à i d h l i g
● 한 국 어
● H r v a t s k i
● I d o
● B a h a s a I n d o n e s i a
● I t a l i a n o
● ע ב ר י ת
● Қ а з а қ ш а
● K i s w a h i l i
● M a g y a r
● მ ა რ გ ა ლ უ რ ი
● م ص ر ى
● م ا ز ِ ر و ن ی
● B a h a s a M e l a y u
● N e d e r l a n d s
● 日 本 語
● N o r s k b o k m å l
● O c c i t a n
● P l a t t d ü ü t s c h
● P o l s k i
● P o r t u g u ê s
● Р у с с к и й
● S i m p l e E n g l i s h
● S l o v e n č i n a
● S l o v e n š č i n a
● S u o m i
● S v e n s k a
● Т а т а р ч а / t a t a r ç a
● T ü r k ç e
● У к р а ї н с ь к а
● ا ر د و
● Y o r ù b á
● 中 文
E d i t l i n k s
● A r t i c l e
● T a l k
E n g l i s h
● R e a d
● E d i t
● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d
● E d i t
● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e
● R e l a t e d c h a n g e s
● U p l o a d f i l e
● S p e c i a l p a g e s
● P e r m a n e n t l i n k
● P a g e i n f o r m a t i o n
● C i t e t h i s p a g e
● G e t s h o r t e n e d U R L
● D o w n l o a d Q R c o d e
● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F
● P r i n t a b l e v e r s i o n
I n o t h e r p r o j e c t s
● W i k i m e d i a C o m m o n s
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Swedish neuroscientist (1923–2018)
Arvid Carlsson (25 January 1923 – 29 June 2018)[2] [3] [4] was a Swedish neuropharmacologist who is best known for his work with the neurotransmitter dopamine and its effects in Parkinson's disease . For his work on dopamine, Carlsson was awarded the Nobel Prize in Physiology or Medicine in 2000, together with Eric Kandel and Paul Greengard .[5] [6]
Early life and education [ edit ]
Carlsson was born on 25 January 1923 in Uppsala , Sweden, one of four siblings. His family moved to Lund after his father became a history professor at Lund University . Although his two older siblings followed their father's career path, he instead chose to study medicine at Lund, beginning in 1941.[4] [7]
In 1944, he participated in the task of examining prisoners of Nazi concentration camps, whom Swedish aristocrat Folke Bernadotte had managed to bring to Sweden, which was neutral during World War II .[4] [7] He received his MD and PhD in pharmacology in 1951.[4]
In 1951, Carlsson became an associate professor at Lund University. He spent five months as a research fellow for the pharmacologist Bernard Beryl Brodie at the National Heart Institute in Bethesda, Maryland , United States, and the change in his research focus to psychopharmacology eventually led to his Nobel Prize.[4] In 1959 he became a professor at the University of Gothenburg .[4] [7]
In 1957 Katharine Montagu demonstrated the presence of dopamine in the human brain; later that same year Carlsson also demonstrated that dopamine was a neurotransmitter in the brain and not just a precursor for norepinephrine .[8] [9] Carlsson went on to develop a method for measuring the amount of dopamine in brain tissues. He found that dopamine levels in the basal ganglia , a brain area important for movement, were particularly high. He then showed that giving animals the drug reserpine caused a decrease in dopamine levels and a loss of movement control. These effects were similar to the symptoms of Parkinson's disease. By administering to these animals L-Dopa , which is the precursor of dopamine, he could alleviate the symptoms. These findings led other doctors to try using L-Dopa in patients with Parkinson's disease, and it was found to alleviate some of the symptoms in the early stages of the disease. L-Dopa is still the basis for most commonly used means of treating Parkinson's disease.[5]
Carlson collaborated with the drug company Astra AB (now AstraZeneca ) during the 1970s and the 1980s.[10] He and his colleagues were able to derive the first marketed selective serotonin reuptake inhibitor (SSRI), zimelidine , from brompheniramine .[5] Zimelidine was later withdrawn from the market due to rare cases of Guillain–Barré syndrome ,[11] but Carlson's research paved the way for fluoxetine (Prozac), one of the most widely used prescription medicines in the world.[7]
Carlsson was still an active researcher and speaker when he was over 90 years old and, together with his daughter Lena, he worked[12] on OSU6162 , a dopamine stabilizer which alleviates symptoms of post-stroke fatigue.[13]
Honours and awards [ edit ]
Carlsson's research on the brain's chemical signals and the resulting treatment for Parkinson's disease earned him the 2000 Nobel Prize in Physiology or Medicine , which he shared with Paul Greengard and Eric R. Kandel .[4] [7] He won many other awards including Israel's Wolf Prize in Medicine (1979), the Japan Prize (1994),[7] and Italy's Feltrinelli Prize (1999).[14] He was elected as a member of the Royal Swedish Academy of Sciences in 1975.[4] He was awarded an honorary Doctor of Science from the University of Southern California in 2007.[15]
Personal life [ edit ]
Carlsson married Ulla-Lisa Christoffersson in 1945 and they had three sons and two daughters. His daughter Maria was his lab manager[4] [7] and his daughter Lena was one of his collaborators.[12]
He opposed the fluoridation of drinking water in Sweden.[16] [17] [18] He was a vocal opponent of homeopathy and worked to prevent homeopathic preparations from being classified as medication in Sweden.[2]
Carlsson died on 29 June 2018, at the age of 95.[4] [7]
References [ edit ]
^ "In memory of Arvid Carlsson (1923-2018)" . Sahlgrenska Academy. Archived from the original on 1 July 2018. Retrieved 30 June 2018 .
^ a b c d e f g h i j Gellene, Denise (1 July 2018). "Arvid Carlsson, Who Discovered a Treatment for Parkinson's, Dies at 95" . The New York Times . Retrieved 3 July 2018 .
^ a b c Barondes, Samuel H. (2003). Better Than Prozac . New York: Oxford University Press. pp. 21–22, 39–40 . ISBN 978-0-19-515130-5 .
^ Les Prix Nobel . 2001. The Nobel Prizes 2000, Editor Tore Frängsmyr, Nobel Foundation: Stockholm.
^ a b c d e f g h Smith, Harrison (2 July 2018). "Arvid Carlsson, Nobel laureate who uncovered a treatment for Parkinson's, dies at 95" . Washington Post . Retrieved 3 July 2018 .
^ Carlsson, Arvid; Lindqvist, Margit; Magnusson, Tor (November 1957). "3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists" . Nature . 180 (4596): 1200. Bibcode :1957Natur.180.1200C . doi :10.1038/1801200a0 . PMID 13483658 . S2CID 28141709 .
^ Abbott A (2007). "Neuroscience: the molecular wake-up call". Nature . 447 (7143): 368–70. Bibcode :2007Natur.447..368A . doi :10.1038/447368a . PMID 17522649 . S2CID 4425376 .
^ Squire, Larry R. (1998). The History of Neuroscience in Autobiography . Elsevier. p. 53. ISBN 978-0-08-053405-3 .
^ "History: Discovery of the SSRIs (long) | Psycho-Babble" . www.dr-bob.org . Retrieved 22 June 2016 .
^ a b "Publications card" . University of Gothenburg . 25 November 2010. Archived from the original on 8 August 2016. Retrieved 22 June 2016 .
^ "Arvid Carlsson and Lena Carlsson" . www.BrainMessenger.se . Retrieved 22 June 2016 .
^ "Accademia Nazionale dei Lincei - Premi e borse di studio - Premi "Antonio Feltrinelli" finora conferiti" . Accademia dei Lincei (in Italian). Archived from the original on 28 July 2014. Retrieved 3 July 2018 .
^ "Past Recipients – Honorary Degrees" . honorarydegrees.usc.edu . Retrieved 8 May 2024 .
^ Fluoride in drinking water can cause cancer, Svenska Dagbladet (in Swedish)
^ Torell P, Forsman B (February 1979). "[Arvid Carlsson's fluoride ponderings 1978]". Tandlakartidningen (in Swedish). 71 (3 ): 142–57. PMID 287207 .
^ Bryson C. (2004) The Fluoride Deception . Seven Stories Press. p. p. 240 . ISBN 1583225269 .
External links [ edit ]
t
e
1901–1925
1926–1950
1951–1975
1976–2000
2001–present
t
e
1970s
1980s
1990s
2000s
2010s
2020s
International
National
Academics
Other
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Arvid_Carlsson&oldid=1222846216 "
C a t e g o r i e s :
● 1 9 2 3 b i r t h s
● 2 0 1 8 d e a t h s
● S w e d i s h n e u r o s c i e n t i s t s
● S w e d i s h p h a r m a c o l o g i s t s
● N o b e l l a u r e a t e s i n P h y s i o l o g y o r M e d i c i n e
● P e o p l e c o n n e c t e d t o L u n d U n i v e r s i t y
● W o l f P r i z e i n M e d i c i n e l a u r e a t e s
● S w e d i s h N o b e l l a u r e a t e s
● A c a d e m i c s t a f f o f t h e U n i v e r s i t y o f G o t h e n b u r g
● M e m b e r s o f t h e R o y a l S w e d i s h A c a d e m y o f S c i e n c e s
● P e o p l e f r o m U p p s a l a
● 2 0 t h - c e n t u r y S w e d i s h s c i e n t i s t s
● 2 1 s t - c e n t u r y S w e d i s h s c i e n t i s t s
● M e m b e r s o f t h e N a t i o n a l A c a d e m y o f M e d i c i n e
● U n i v e r s i t y o f G o t h e n b u r g a l u m n i
H i d d e n c a t e g o r i e s :
● C S 1 I t a l i a n - l a n g u a g e s o u r c e s ( it )
● C S 1 S w e d i s h - l a n g u a g e s o u r c e s ( sv )
● A r t i c l e s w i t h s h o r t d e s c r i p t i o n
● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a
● U s e d m y d a t e s f r o m J u l y 2 0 1 8
● A r t i c l e s w i t h h C a r d s
● C o m m o n s c a t e g o r y l i n k i s o n W i k i d a t a
● N o b e l p r i z e t e m p l a t e u s i n g W i k i d a t a p r o p e r t y P 8 0 2 4
● A r t i c l e s w i t h I S N I i d e n t i f i e r s
● A r t i c l e s w i t h V I A F i d e n t i f i e r s
● A r t i c l e s w i t h W o r l d C a t E n t i t i e s i d e n t i f i e r s
● A r t i c l e s w i t h B I B S Y S i d e n t i f i e r s
● A r t i c l e s w i t h B N F i d e n t i f i e r s
● A r t i c l e s w i t h B N F d a t a i d e n t i f i e r s
● A r t i c l e s w i t h G N D i d e n t i f i e r s
● A r t i c l e s w i t h J 9 U i d e n t i f i e r s
● A r t i c l e s w i t h L C C N i d e n t i f i e r s
● A r t i c l e s w i t h L i b r i s i d e n t i f i e r s
● A r t i c l e s w i t h N D L i d e n t i f i e r s
● A r t i c l e s w i t h N K C i d e n t i f i e r s
● A r t i c l e s w i t h N S K i d e n t i f i e r s
● A r t i c l e s w i t h N T A i d e n t i f i e r s
● A r t i c l e s w i t h P L W A B N i d e n t i f i e r s
● A r t i c l e s w i t h V c B A i d e n t i f i e r s
● A r t i c l e s w i t h C I N I I i d e n t i f i e r s
● A r t i c l e s w i t h S U D O C i d e n t i f i e r s
● T h i s p a g e w a s l a s t e d i t e d o n 8 M a y 2 0 2 4 , a t 0 7 : 4 4 ( U T C ) .
● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n .
● P r i v a c y p o l i c y
● A b o u t W i k i p e d i a
● D i s c l a i m e r s
● C o n t a c t W i k i p e d i a
● C o d e o f C o n d u c t
● D e v e l o p e r s
● S t a t i s t i c s
● C o o k i e s t a t e m e n t
● M o b i l e v i e w