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Names | |
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Preferred IUPAC name
2,3-Dihydroxy-3-methylpentanoic acid | |
Identifiers | |
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3D model (JSmol) |
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ChemSpider |
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KEGG |
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MeSH | 2,3-dihydroxy-3-methylpentanoic+acid |
PubChem CID |
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CompTox Dashboard (EPA) |
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Properties | |
C6H12O4 | |
Molar mass | 148.16 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
2,3-Dihydroxy-3-methylpentanoic acid is an intermediate in the metabolism of isoleucine.
2,3-Dihydroxy-3-methylpentanoate is synthesized by the action of acetolactate mutase with subsequent reduction from α-aceto-α-hydroxybutyrate through 3-hydroxy-2-keto-3-methylpentanoate:[1]
It is then processed by the action of dihydroxyacid dehydratase, which results in 2-keto-3-methylvalerate and water:[1]
Transamination of 2-keto-3-methylvalerate yields isoleucine.
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