Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[5]
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[6]
HDAC1 has been shown to interact with:
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
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3.5.1: Linear amides / Amidohydrolases |
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3.5.2: Cyclic amides/ Amidohydrolases |
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3.5.3: Linear amidines/ Ureohydrolases |
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3.5.4: Cyclic amidines/ Aminohydrolases |
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3.5.5: Nitriles/ Aminohydrolases |
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3.5.99: Other |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Types |
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