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Contents

   



(Top)
  


1 See also  




2 References  













Ketipramine






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From Wikipedia, the free encyclopedia
  

Ketipramine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Identifiers

  • 5-[3-(dimethylamino)propyl]-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one

CAS Number
  • Fumarate salt: 17243-32-2 checkY
    • PubChem CID
    ChemSpider
    UNII
  • Fumarate salt: 86490E9X8J checkY
    • CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC19H22N2O
    Molar mass294.398 g·mol−1
    3D model (JSmol)

    • O=C3c1c(cccc1)N(c2c(cccc2)C3)CCCN(C)C

    Ketipramine (G-35,259), also known as ketimipramineorketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed.[1][2][3] It differs from imipramine in terms of chemical structure only by the addition of a ketone group, to the azepine ring, and is approximately equivalent in effectiveness as an antidepressant in comparison.[4]

    It was one of the drugs prescribed by Roland Kuhn in a series of unethical experiments to test drugs on children without informed consent and without proper approval at the psychiatric hospital in Münsterlingen, Switzerland.[5][6][7]

    See also[edit]

    References[edit]

    1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  • ^ Simeon J, Fuchs M, Nikolovski O, Bucci L (1970). "Ketipramine in the therapy of depression in outpatients". Psychosomatics. 11 (4): 342–6. doi:10.1016/S0033-3182(70)71634-4. PMID 5459338. Archived from the original on 2011-07-27.
  • ^ Park S, Glick B, Floyd A, Gershon S (May 1971). "Ketipramine fumarate as compared to imipramine in depressed outpatients". Current Therapeutic Research, Clinical and Experimental. 13 (5): 322–5. PMID 4998396.
  • ^ Author Unknown (1971). Ann Reports Medicinal Chem V6 (v. 6). Boston: Academic Press. ISBN 0-12-040506-7. {{cite book}}: |author= has generic name (help)
  • ^ Die Experimente von Münsterlingen 20. November 2012. Tages-Anzeiger
  • ^ Münsterlingen: Alles noch viel schlimmer
  • ^ Simone Rau: Das Ausmass der Medi-Versuche in Münsterlingen ist weit grösser. In: Der Bund, 31. Oktober 2016.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Ketipramine&oldid=1170992082"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Dimethylamino compounds
     ●Antidepressants
     ●Dibenzazepines
     ●Ketones
     ●Tricyclic antidepressants
     Hidden categories: 
    ●CS1 errors: generic name
     ●Articles with short description
     ●Short description matches Wikidata
     ●Articles without EBI source
     ●Chemical pages without DrugBank identifier
     ●Articles without KEGG source
     ●Articles without InChI source
     ●Multiple chemicals in Infobox drug
     ●Chemicals using indexlabels
     ●Chemical articles with multiple CAS registry numbers
     ●Drugs with no legal status
     ●Articles containing unverified chemical infoboxes
      


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