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Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome . It works by relaxing the muscles in and around the gut.[1]
Medical use [ edit ]
Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps, persistent diarrhoea, and flatulence.[2]
Data from controlled clinical trials have not found a difference from placebo or statistically significant results in the global improvement of IBS.[3] [4]
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.[1]
Adverse effects [ edit ]
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, oedema and widespread rashes.[2]
Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhoea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.[1]
It does not have systemic anticholinergic side effects.[2]
Mebeverine can, on highly rare occasions, cause drug-induced acute angle closure glaucoma.[5]
In a urine drug-screening test, mebeverine can affect a false positive result for amphetamines.[6]
Mechanism of action [ edit ]
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anaesthetic effect, may affect calcium channels , and may affect muscarinic receptors.[2]
It is metabolized mostly by esterases , and almost completely. The metabolites are excreted in urine.[2]
Mebeverine exists in two enantiomeric forms. The commercially available product is a racemic mixture of them. A study in rats indicates that the two have different pharmacokinetic profiles.[7]
History [ edit ]
It is a second generation papaverine analog, and was first synthesized around the same time as verapamil .[8]
It was first registered in 1965.[9]
Availability [ edit ]
Mebeverine is a generic drug and is available internationally under many brand names such as in Bangladesh it sold as Mave and Mave SR.[10]
References [ edit ]
^ a b c "Colofac data sheet" (PDF) . New Zealand Medicines and Medical Devices Safety Authority. 14 June 2017. Retrieved 21 July 2017 .
^ a b c d e "Colofac Tablets 135mg - Summary of Product Characteristics (SPC)" . UK Electronic Medicines Compendium. 26 August 2016. Retrieved 21 July 2017 .
^ Annaházi A, Róka R, Rosztóczy A, Wittmann T (May 2014). "Role of antispasmodics in the treatment of irritable bowel syndrome" . World Journal of Gastroenterology . 20 20 ): 6031–43. doi :10.3748/wjg.v20.i20.6031 PMC 4033443 PMID 24876726 .
^ Darvish-Damavandi M, Nikfar S, Abdollahi M (February 2010). "A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome" . World Journal of Gastroenterology . 16 5 ): 547–53. doi :10.3748/wjg.v16.i5.547 PMC 2816265 PMID 20128021 .
^ Lachkar Y, Bouassida W (March 2007). "Drug-induced acute angle closure glaucoma". Current Opinion in Ophthalmology . 18 2 ): 129–33. doi :10.1097/ICU.0b013e32808738d5 . PMID 17301614 . S2CID 30903966 .
^ Optimisation, NECS Medicines (2015-07-21). "Misuse of hyoscine butylbromide (Buscopan) |" . medicines.necsu.nhs.uk . Retrieved 2018-02-07 .
^ Hatami M, Farhadi K, Tukmechi A (August 2012). "Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma". Chirality . 24 8 ): 634–9. doi :10.1002/chir.22057 . PMID 22700279 .
^ Sneader W (2005). Drug Discovery: A History ISBN 9780471899792
^ "Mebeverine" . druginfosys . Retrieved 1 February 2015 .
^ "Mebeverine" . International . drugs.com. Retrieved 1 February 2015 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Mebeverine&oldid=1219541983 " C a t e g o r i e s : ● A m i n e s ● B e n z o a t e e s t e r s ● M o t i l i t y s t i m u l a n t s ● M u s c a r i n i c a n t a g o n i s t s ● C a t e c h o l e t h e r s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● D r u g s w i t h n o n - s t a n d a r d l e g a l s t a t u s ● E C H A I n f o C a r d I D f r o m W i k i d a t a ● C h e m i c a l p a g e s w i t h o u t D r u g B a n k i d e n t i f i e r ● M u l t i p l e c h e m i c a l s i n I n f o b o x d r u g ● C h e m i c a l s u s i n g i n d e x l a b e l s ● C h e m i c a l a r t i c l e s w i t h m u l t i p l e C A S r e g i s t r y n u m b e r s ● D r u g b o x e s w h i c h c o n t a i n c h a n g e s t o w a t c h e d f i e l d s
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