Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Medical use 2 Names 3 References

Dimetindene

●العربية ●Deutsch ●Ελληνικά ●فارسی ●Italiano ●עברית ●Magyar ●Nederlands ●Polski ●Português ●Română ●Српски / srpski ●Srpskohrvatski / српскохрватски ●ไทย ●Українська ●Tiếng Việt ●中文 Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version In other projects ●Wikimedia Commons Appearance From Wikipedia, the free encyclopedia

Dimetindene
Clinical data

Trade names	Fenistil
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	D04AA13 (WHO) R06AB03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: General sales list (GSL, OTC)
Identifiers
IUPAC name N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number	5636-83-9^Y 3614-69-5
PubChem CID	21855
DrugBank	DB08801^Y
ChemSpider	20541^Y
UNII	661FH77Z3P
KEGG	D07853^Y
ChEMBL	ChEMBL22108^Y
CompTox Dashboard (EPA)	DTXSID9022942
ECHA InfoCard	100.024.622
Chemical and physical data
Formula	C₂₀H₂₄N₂
Molar mass	292.426 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3^Y Key:MVMQESMQSYOVGV-UHFFFAOYSA-N^Y
(verify)

Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation^[1] selective H1 antagonist.^[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally^[3] passes across the blood–brain barrier.

Dimetindene is also an M2 receptor antagonist.^[4]

It was patented in 1958 and came into medical use in 1960.^[5]

Medical use[edit]

Dimetindene is used orally and topically as an antipruritic.^[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.

Names[edit]

It is sold under the brand name Fenistil among others.

References[edit]

^ Fromer LM, Ortiz GR, Dowdee AM (September 2008). "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey". The World Allergy Organization Journal. 1 (9): 156–159. doi:10.1186/1939-4551-1-9-145. PMC 3651039. PMID 23282579.

^ "Dimetindene". Drugs.com.

^ Noguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628. S2CID 29562845.

^ Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N (April 2010). "Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats". Urology. 75 (4): 862–867. doi:10.1016/j.urology.2009.12.013. PMC 2871158. PMID 20156651.

^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495.

^ Wexler L (June 1962). "A clinical evaluation of dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–309. PMID 14006402.

Antipruritics (D04)

Antihistamines for topical use

Anesthetics for topical use

Others

Corticosteroids (e.g., hydrocortisone)
Counterirritants (e.g., mint oil, menthol, camphor)
Difelikefalin
Doxepin
Nalfurafine

v t e Antihistamines (R06)
Benzimidazoles (*)	Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine
Diarylmethanes	Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine) Carbinoxamine Chlorphenoxamine Clemastine Diphenhydramine (+naproxen) Diphenylpyraline Doxylamine Ebastine Orphenadrine Diphenylmethanolpiperidines: Fexofenadine Terfenadine Diphenylmethylpiperazines: Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Etodroxizine Hydroxyzine Meclizine Oxatomide Phenylpyridinylpropanamines: Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Pheniramine Others: Acrivastine Bamipine Dimetindene Phenyltoloxamine Pyrrobutamine Quifenadine Triprolidine
Ethylenediamines	Antazoline Chloropyramine Histapyrrodine Mepyramine (pyrilamine) Methapyrilene Phenbenzamine Thenalidine Tripelennamine (pyribenzamine)
Tricyclics	Dibenzocycloheptenes: Antidepressants (e.g., amitriptyline) Azatadine Cyproheptadine Deptropine Desloratadine Ketotifen Loratadine Rupatadine Phenothiazines: Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene
Others	Phenylpiperazines: Antidepressants (e.g., trazodone) Phenbenzamine
For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine