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Formula | C14H14ClN3O2 |
Molar mass | 291.74 g·mol−1 |
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PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys,[1] It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsantoranxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.[2]
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1,4-Benzodiazepines |
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1,5-Benzodiazepines |
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2,3-Benzodiazepines* |
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Triazolobenzodiazepines |
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Imidazobenzodiazepines |
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Oxazolobenzodiazepines |
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Thienodiazepines |
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Thienotriazolodiazepines |
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Thienobenzodiazepines* |
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Pyridodiazepines |
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Pyridotriazolodiazepines |
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Pyrazolodiazepines |
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Pyrrolodiazepines |
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Tetrahydroisoquinobenzodiazepines |
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Pyrrolobenzodiazepines* |
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Benzodiazepine prodrugs |
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* atypical activity profile (not GABAA receptor ligands) |
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