![]() | |
Clinical data | |
---|---|
Pregnancy category |
|
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG |
|
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.221.150 ![]() |
Chemical and physical data | |
Formula | C19H26ClNO6 |
Molar mass | 399.87 g·mol−1 |
3D model (JSmol) | |
| |
|
Arbaclofen placarbil (/ɑːrˈbækloʊfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrugofR-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1]
It is being developed as an addiction medicine to treat alcoholism. [2] It is also studied as a potential therapeutic for some autistic subjects.[3]
| |
---|---|
H2 antagonists ("-tidine") |
|
Prostaglandins (E)/ analogues ("-prost-") |
|
Proton-pump inhibitors ("-prazole") |
|
Potassium-competitive acid blockers ("-prazan") |
|
Others |
|
Combinations |
|
| |
|
| |||||
---|---|---|---|---|---|
Ionotropic |
| ||||
Metabotropic |
| ||||
|
| |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium |
| ||||||||||||||||||||||||
Potassium |
| ||||||||||||||||||||||||
Sodium |
| ||||||||||||||||||||||||
Chloride |
| ||||||||||||||||||||||||
Others |
| ||||||||||||||||||||||||
See also: Receptor/signaling modulators • Transient receptor potential channel modulators |
![]() | This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. |
![]() | This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it. |