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Contents

   



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1 See also  




2 References  













RU-57073






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From Wikipedia, the free encyclopedia
  

RU-57073
Clinical data
Drug classNonsteroidal antiandrogen
Identifiers

  • 4-[3-(2-Hydroxyethyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H14F3N3O2S
Molar mass357.35 g·mol−1
3D model (JSmol)

  • CC1(C(=O)N(C(=S)N1CCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C

  • InChI=1S/C15H14F3N3O2S/c1-14(2)12(23)21(13(24)20(14)5-6-22)10-4-3-9(8-19)11(7-10)15(16,17)18/h3-4,7,22H,5-6H2,1-2H3

  • Key:HNTMVNIRYPJDDJ-UHFFFAOYSA-N

RU-57073 is a nonsteroidal antiandrogen which was never marketed.[1][2][3] It shows 163% of the affinityoftestosterone for the androgen receptor and negligible affinity for other steroid hormone receptors.[1][2]

See also[edit]

References[edit]

  1. ^ a b Singh SM, Gauthier S, Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. doi:10.2174/0929867003375371. PMID 10637363.
  • ^ a b Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D (January 1994). "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". J. Steroid Biochem. Mol. Biol. 48 (1): 111–9. doi:10.1016/0960-0760(94)90257-7. PMID 8136296. S2CID 31404295.
  • ^ Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID 15700772.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=RU-57073&oldid=1135138229"
    Categories: 
    ●Abandoned drugs
     ●Primary alcohols
     ●Ketones
     ●Imidazolines
     ●Nitriles
     ●Nonsteroidal antiandrogens
     ●Organosulfur compounds
     ●Trifluoromethyl compounds
     ●Genito-urinary system drug stubs
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