| |
| Names | |
|---|---|
| IUPAC name
S-(5′-Deoxyadenos-5′-yl)-L-homocysteine | |
| Systematic IUPAC name
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid | |
| Other names
AdoHcy, 2-S-adenosyl-L-homocysteine, | |
| Identifiers | |
| |
3D model (JSmol) |
|
| ChEBI | |
| ChEMBL | |
| ChemSpider |
|
| ECHA InfoCard | 100.012.328 
|
| KEGG |
|
| MeSH | S-Adenosylhomocysteine |
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
| Properties | |
| C14H20N6O5S | |
| Molar mass | 384.41 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
S-Adenosyl-L-homocysteine (SAH) is the biosynthetic precursor to homocysteine.[1] SAH is formed by the demethylationofS-adenosyl-L-methionine.[2][3] Adenosylhomocysteinase converts SAH into homocysteine and adenosine.
DNA methyltransferases are inhibited by SAH.[4] Two S-adenosyl-L-homocysteine cofactor products can bind the active site of DNA methyltransferase 3B and prevent the DNA duplex from binding to the active site, which inhibits DNA methylation.[5]
|
| |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| K→acetyl-CoA |
| ||||||||||||||||||||||||||||||||
| G |
| ||||||||||||||||||||||||||||||||
| Other |
| ||||||||||||||||||||||||||||||||
 | This biochemistry article is a stub. You can help Wikipedia by expanding it. |
