コレラ毒素

出典: フリー百科事典『ウィキペディア(Wikipedia)』

: cholera toxin:CTXCtxCTVibrio choleraeAB5[1][2]便[3]

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1886[4]1951 Sambhu Nath De[5]De[5]De1959[6][7]

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B

1A5BAB5B宿AG1995X[8]

B11 kDa5BA28 kDa2A1CTA1GADPA2CTA2αB[9]


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BGM1GM1XY[10][11][12]A1A1A1Ero1A1[13]A1Sec61

A1ARF6宿ARF6A1[14]A1NADGsαGαsADPADPGαsGTPGDPPiGαsGαscAMP100PKAPKACFTRATPH2ONa+K+HCO3 Na+2 L便rice water stool[15]

Bordetella pertussisAB5GiαGαiADPcAMP[16]

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RS1CTXφf1[17]

O1O139CTXφ[17]CTXφRS1rstArstB調rstRPshCepOrfUAceZotFf[17]CTXφCTXφ[17]

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BCTB[18]

Hes3[19]

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DukoralShanchol使DukoralBrCTBrCTB210rCTB[20]

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CTBCTBCTBCTB尿CTBHIV[20]

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GM1寿GM1CTBCTB[21]

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clathrin-coated pitCLICclathrin-independent carrierGEECGPI-enriched endocytic compartmentARF6FEMEfast endophilin-mediated endocytosis[21]

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1GM1[21]

出典[編集]

  1. ^ Ryan KJ; Ray CG, eds (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. p. 375. ISBN 978-0-8385-8529-0 
  2. ^ Faruque, Shah M; Nair, G. Balakrish, eds (July 2008). Vibrio cholerae: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-33-2. https://www.caister.com/vib 
  3. ^ Aizpurua-Olaizola, Oier; Sastre Torano, Javier; Pukin, Aliaksei; Fu, Ou; Boons, Geert Jan; de Jong, Gerhardus J.; Pieters, Roland J. (2018). “Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors” (英語). Electrophoresis 39 (2): 344–347. doi:10.1002/elps.201700207. ISSN 1522-2683. PMID 28905402. 
  4. ^ Bharati, Kaushik; Ganguly, Nirmal K. (February 2011). “Cholera toxin: A paradigm of a multifunctional protein”. The Indian Journal of Medical Research 133 (2): 179–187. ISSN 0971-5916. PMC 3089049. PMID 21415492. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089049/. 
  5. ^ a b De, S. N.; Sarkar, J. K.; Tribedi, B. P. (1951). “An experimental study of the action of cholera toxin”. The Journal of Pathology and Bacteriology 63 (4): 707–717. doi:10.1002/path.1700630417. PMID 14898376. 
  6. ^ De, S. N. (1959-05-30). “Enterotoxicity of bacteria-free culture-filtrate of Vibrio cholerae”. Nature 183 (4674): 1533–1534. doi:10.1038/1831533a0. ISSN 0028-0836. PMID 13666809. https://pubmed.ncbi.nlm.nih.gov/13666809/. 
  7. ^ Bharati, Kaushik; Ganguly, Nirmal K. (February 2011). “Cholera toxin: A paradigm of a multifunctional protein”. The Indian Journal of Medical Research 133 (2): 179–187. ISSN 0971-5916. PMC 3089049. PMID 21415492. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089049/. 
  8. ^ “The three-dimensional crystal structure of cholera toxin”. J Mol Biol 251 (4): 563–73. (1995). doi:10.1006/jmbi.1995.0456. PMID 7658473. https://digital.library.unt.edu/ark:/67531/metadc667167/. 
  9. ^ “Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review)”. Mol. Membr. Biol. 21 (2): 77–92. (2004). doi:10.1080/09687680410001663267. PMID 15204437. 
  10. ^ Amberlyn M Wands; Akiko Fujita (October 2015). “Fucosylation and protein glycosylation create functional receptors for Cholera toxin”. eLife 4: e09545. doi:10.7554/eLife.09545. PMC 4686427. PMID 26512888. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686427/. 
  11. ^ “GM1 ganglioside-independent intoxication by Cholera toxin”. PLOS Pathogens 14 (2): e1006862. (2018). doi:10.1371/journal.ppat.1006862. PMC 5825173. PMID 29432456. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825173/. 
  12. ^ “Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells”. ACS Infectious Diseases 4 (5): 758–770. (February 7, 2018). doi:10.1021/acsinfecdis.7b00085. PMC 5948155. PMID 29411974. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948155/. 
  13. ^ Tsai, Billy; Rapoport, Tom A. (2002). “Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1”. Journal of Cell Biology 159 (2): 207–216. doi:10.1083/jcb.200207120. PMC 2173060. PMID 12403808. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173060/. 
  14. ^ “Structural basis for the activation of cholera toxin by human ARF6-GTP”. Science 309 (5737): 1093–6. (2005). Bibcode2005Sci...309.1093O. doi:10.1126/science.1113398. PMID 16099990. 
  15. ^ Joaquín Sánchez; Jan Holmgren (February 2011). “Cholera toxin – A foe & a friend”. Indian Journal of Medical Research 133: 158. オリジナルの2013-02-03時点におけるアーカイブ。. https://web.archive.org/web/20130203143806/http://icmr.nic.in/ijmr/2011/february/0204.pdf 2013年6月9日閲覧。. 
  16. ^ Boron, Walter F.; Boulpaep, Emile L., eds (2009). Medical physiology: a cellular and molecular approach (2nd ed., International ed ed.). Philadelphia, PA: Saunders/Elsevier. ISBN 978-1-4160-3115-4. OCLC 190860094. https://www.worldcat.org/title/190860094 
  17. ^ a b c d Davis, Brigid M; Waldor, Matthew K (2003-02-01). “Filamentous phages linked to virulence of Vibrio cholerae”. Current Opinion in Microbiology 6 (1): 35–42. doi:10.1016/S1369-5274(02)00005-X. ISSN 1369-5274. https://www.sciencedirect.com/science/article/pii/S136952740200005X. 
  18. ^ Pierre-Hervé Luppi. “The Discovery of Cholera-Toxin as a Powerful Neuroanatomical Tool”. 2011年3月23日閲覧。
  19. ^ “Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains”. PLOS ONE 5 (5): e10841. (2010). Bibcode2010PLoSO...510841A. doi:10.1371/journal.pone.0010841. PMC 2877108. PMID 20520777. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877108/. 
  20. ^ a b Baldauf, Keegan; Royal, Joshua; Hamorsky, Krystal; Matoba, Nobuyuki (2015). “Cholera Toxin B: One Subunit with Many Pharmaceutical Applications”. Toxins 7 (3): 974–996. doi:10.3390/toxins7030974. PMC 4379537. PMID 25802972. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379537/. 
  21. ^ a b c Kenworthy, Anne K.; Schmieder, Stefanie S.; Raghunathan, Krishnan; Tiwari, Ajit; Wang, Ting; Kelly, Christopher V.; Lencer, Wayne I. (2021). “Cholera Toxin as a Probe for Membrane Biology”. Toxins 13 (8): 543. doi:10.3390/toxins13080543. PMC 8402489. PMID 34437414. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402489/. 

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外部リンク[編集]