MED1: Difference between revisions

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'''Mediator complex subunit 1''', also known as '''MED1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref>

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| section_title =

| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.<ref name="entrez">{{cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref>

==Interactions==

MED1 has been shown to [[Protein-protein_interaction|interact]] with [[Thyroid hormone receptor alpha]],<ref name=pmid9653119>{{cite journal | quotes = yes |last=Yuan |first=C X |authorlink= |coauthors=Ito M, Fondell J D, Fu Z Y, Roeder R G |year=[[1998]]|month=Jul. |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=14 |pages=7939-44 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9653119 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Androgen receptor]],<ref name=pmid12218053>{{cite journal | quotes = yes |last=Wang |first=Qianben |authorlink= |coauthors=Sharma Dipali, Ren Yunsheng, Fondell Joseph D |year=[[2002]]|month=Nov. |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue=45 |pages=42852-8 |publisher= |location = United States| issn = 0021-9258| pmid = 12218053 |doi = 10.1074/jbc.M206061200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin-dependent kinase 8]],<ref name=pmid10198638>{{cite journal | quotes = yes |last=Ito |first=M |authorlink= |coauthors=Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G |year=[[1999]]|month=Mar. |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue=3 |pages=361-70 |publisher= |location = UNITED STATES| issn = 1097-2765| pmid = 10198638 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11867769>{{cite journal | quotes = yes |last=Kang |first=Yun Kyoung |authorlink= |coauthors=Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G |year=[[2002]]|month=Mar. |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642-7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Glucocorticoid receptor]],<ref name=pmid11266503>{{cite journal | quotes = yes |last=Zilliacus |first=J |authorlink= |coauthors=Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A |year=[[2001]]|month=Apr. |title=Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 |journal=Mol. Endocrinol. |volume=15 |issue=4 |pages=501-11 |publisher= |location = United States| issn = 0888-8809| pmid = 11266503 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10508170>{{cite journal | quotes = yes |last=Hittelman |first=A B |authorlink= |coauthors=Burakov D, Iñiguez-Lluhí J A, Freedman L P, Garabedian M J |year=[[1999]]|month=Oct. |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins |journal=EMBO J. |volume=18 |issue=19 |pages=5380-8 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10508170 |doi = 10.1093/emboj/18.19.5380 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BRCA1]],<ref name=pmid15208681>{{cite journal | quotes = yes |last=Wada |first=Osamu |authorlink= |coauthors=Oishi Hajime, Takada Ichiro, Yanagisawa Junn, Yano Tetsu, Kato Shigeaki |year=[[2004]]|month=Aug. |title=BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220 |journal=Oncogene |volume=23 |issue=35 |pages=6000-5 |publisher= |location = England| issn = 0950-9232| pmid = 15208681 |doi = 10.1038/sj.onc.1207786 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Hepatocyte nuclear factor 4 alpha]],<ref name=pmid12089346>{{cite journal | quotes = yes |last=Maeda |first=Yutaka |authorlink= |coauthors=Rachez Christophe, Hawel Leo, Byus Craig V, Freedman Leonard P, Sladek Frances M |year=[[2002]]|month=Jul. |title=Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205 |journal=Mol. Endocrinol. |volume=16 |issue=7 |pages=1502-10 |publisher= |location = United States| issn = 0888-8809| pmid = 12089346 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12101254>{{cite journal | quotes = yes |last=Malik |first=Sohail |authorlink= |coauthors=Wallberg Annika E, Kang Yun Kyoung, Roeder Robert G |year=[[2002]]|month=Aug. |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 |journal=Mol. Cell. Biol. |volume=22 |issue=15 |pages=5626-37 |publisher= |location = United States| issn = 0270-7306| pmid = 12101254 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Peroxisome proliferator-activated receptor gamma]],<ref name=pmid10944516>{{cite journal | quotes = yes |last=Kodera |first=Y |authorlink= |coauthors=Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S |year=[[2000]]|month=Oct. |title=Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators |journal=J. Biol. Chem. |volume=275 |issue=43 |pages=33201-4 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10944516 |doi = 10.1074/jbc.C000517200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPARGC1A]],<ref name=pmid14636573>{{cite journal | quotes = yes |last=Wallberg |first=Annika E |authorlink= |coauthors=Yamamura Soichiro, Malik Sohail, Spiegelman Bruce M, Roeder Robert G |year=[[2003]]|month=Nov. |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue=5 |pages=1137-49 |publisher= |location = United States| issn = 1097-2765| pmid = 14636573 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[P53]],<ref name=pmid11118038>{{cite journal | quotes = yes |last=Frade |first=R |authorlink= |coauthors=Balbo M, Barel M |year=[[2000]]|month=Dec. |title=RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity |journal=Cancer Res. |volume=60 |issue=23 |pages=6585-9 |publisher= |location = United States| issn = 0008-5472| pmid = 11118038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9444950>{{cite journal | quotes = yes |last=Drané |first=P |authorlink= |coauthors=Barel M, Balbo M, Frade R |year=[[1997]]|month=Dec. |title=Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 |journal=Oncogene |volume=15 |issue=25 |pages=3013-24 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 9444950 |doi = 10.1038/sj.onc.1201492 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Estrogen receptor alpha]],<ref name=pmid12837248>{{cite journal | quotes = yes |last=Kitagawa |first=Hirochika |authorlink= |coauthors=Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki |year=[[2003]]|month=Jun. |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome |journal=Cell |volume=113 |issue=7 |pages=905-17 |publisher= |location = United States| issn = 0092-8674| pmid = 12837248 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11867769/> [[TGS1]]<ref name=pmid11912212>{{cite journal | quotes = yes |last=Misra |first=Parimal |authorlink= |coauthors=Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K |year=[[2002]]|month=May. |title=Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation |journal=J. Biol. Chem. |volume=277 |issue=22 |pages=20011-9 |publisher= |location = United States| issn = 0021-9258| pmid = 11912212 |doi = 10.1074/jbc.M201739200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Calcitriol receptor]].<ref name=pmid12837248/><ref name=pmid10198638/>

==References==

{{reflist}}

==Further reading==

{{refbegin | 2}}

{{PBB_Further_reading

| citations =

*{{cite journal | author=Lee JW, Choi HS, Gyuris J, ''et al.'' |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243–54 |year= 1995 |pmid= 7776974 |doi=10.1210/me.9.2.243 }}

*{{cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329 }}

*{{cite journal | author=Zhu Y, Qi C, Jain S, ''et al.'' |title=Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25500–6 |year= 1997 |pmid= 9325263 |doi=10.1074/jbc.272.41.25500 }}

*{{cite journal | author=Drané P, Barel M, Balbo M, Frade R |title=Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53. |journal=Oncogene |volume=15 |issue= 25 |pages= 3013–24 |year= 1998 |pmid= 9444950 |doi= 10.1038/sj.onc.1201492 }}

*{{cite journal | author=Yuan CX, Ito M, Fondell JD, ''et al.'' |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7939–44 |year= 1998 |pmid= 9653119 |doi=10.1073/pnas.95.14.7939 }}

*{{cite journal | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446–50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141 }}

*{{cite journal | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1 }}

*{{cite journal | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=10.1016/S1097-2765(00)80463-3 }}

*{{cite journal | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}

*{{cite journal | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}

*{{cite journal | author=Atkins GB, Hu X, Guenther MG, ''et al.'' |title=Coactivators for the orphan nuclear receptor RORalpha. |journal=Mol. Endocrinol. |volume=13 |issue= 9 |pages= 1550–7 |year= 1999 |pmid= 10478845 |doi=10.1210/me.13.9.1550 }}

*{{cite journal | author=Zhu Y, Qi C, Jain S, ''et al.'' |title=Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 19 |pages= 10848–53 |year= 1999 |pmid= 10485914 |doi=10.1073/pnas.96.19.10848 }}

*{{cite journal | author=Rachez C, Gamble M, Chang CP, ''et al.'' |title=The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 8 |pages= 2718–26 |year= 2000 |pmid= 10733574 |doi=10.1128/MCB.20.8.2718-2726.2000 }}

*{{cite journal | author=Frade R, Balbo M, Barel M |title=RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. |journal=Cancer Res. |volume=60 |issue= 23 |pages= 6585–9 |year= 2001 |pmid= 11118038 |doi= }}

*{{cite journal | author=Zilliacus J, Holter E, Wakui H, ''et al.'' |title=Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 501–11 |year= 2001 |pmid= 11266503 |doi=10.1210/me.15.4.501 }}

*{{cite journal | author=Crawford SE, Qi C, Misra P, ''et al.'' |title=Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3585–92 |year= 2002 |pmid= 11724781 |doi= 10.1074/jbc.M107995200 }}

*{{cite journal | author=Frade R, Balbo M, Barel M |title=RB18A regulates p53-dependent apoptosis. |journal=Oncogene |volume=21 |issue= 6 |pages= 861–6 |year= 2002 |pmid= 11840331 |doi= 10.1038/sj.onc.1205177 }}

*{{cite journal | author=Kang YK, Guermah M, Yuan CX, Roeder RG |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2642–7 |year= 2002 |pmid= 11867769 |doi= 10.1073/pnas.261715899 }}

*{{cite journal | author=Misra P, Qi C, Yu S, ''et al.'' |title=Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 20011–9 |year= 2002 |pmid= 11912212 |doi= 10.1074/jbc.M201739200 }}

*{{cite journal | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563–7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}

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