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Contents

   



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1 See also  




2 References  













A-41988






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From Wikipedia, the free encyclopedia
  

A-41988
Identifiers

  • 8-[5-(4-Fluorophenyl)pentan-2-yl]-5,5-dimethyl-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H32FNO2
Molar mass433.567 g·mol−1
3D model (JSmol)

  • c4cc(F)ccc4CCCC(C)c3cc(O)c1C=2CN(CC#C)CCC=2C(C)(C)Oc1c3

  • InChI=1S/C28H32FNO2/c1-5-14-30-15-13-24-23(18-30)27-25(31)16-21(17-26(27)32-28(24,3)4)19(2)7-6-8-20-9-11-22(29)12-10-20/h1,9-12,16-17,19,31H,6-8,13-15,18H2,2-4H3 checkY

  • Key:UIDOJGIFVOOMLY-UHFFFAOYSA-N checkY

  (verify)

A-41988 (BW29Y) is an analgesic drug which acts as a cannabinoid agonist. It was developed by Abbott Laboratories in the 1970s,[1][2] and researched for potential use in the treatment of glaucoma,[3] but never commercialised.

See also

[edit]

References

[edit]
  1. ^ Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, et al. (April 1976). "Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains". Journal of Medicinal Chemistry. 19 (4): 461–71. doi:10.1021/jm00226a003. PMID 817021.
  • ^ Guterman A, Somani P, Bachand RT (1979). "Phase-I evaluation of 5-5-dimethyl-10-hydroxy-8-[5-(4-fluorophenyl)-2-pentyl]-2-(2-propynyl-1, 2, 3, 4-tetrahydro-5h-[1] benzopyrano [3, 4-d] pyridine (a-41988)-novel benzopyran derivative". Clinical Pharmacology and Therapeutics. 25: 227.
  • ^ Tiedeman JS, Shields MB, Weber PA, Crow JW, Cocchetto DM, Harris WA, Howes JF (March 1981). "Effect of synthetic cannabinoids on elevated intraocular pressure". Ophthalmology. 88 (3): 270–7. doi:10.1016/s0161-6420(81)35052-0. PMID 7015221.


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