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O-1238






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From Wikipedia, the free encyclopedia
  

O-1238
Identifiers

  • (6aR)-3-[(Z)-6-Azidohex-2-enyl]-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol

PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H29N3O2
Molar mass367.493 g·mol−1
3D model (JSmol)

  • CC3=CCC2C(C)(C)Oc(c1C2C3)cc(cc1O)CC=CCCCN=N=N

  (verify)

O-1238 is a drug which is a cannabinoid derivative that is used in scientific research. It is a partial agonist at the cannabinoid receptor CB1,[1] producing a maximal stimulation of 58.3%[2] with a Ki of 8.45 nM.[3]

References[edit]

  1. ^ Griffin G, Wray EJ, Martin BR, Abood ME (October 1999). "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British Journal of Pharmacology. 128 (3): 684–8. doi:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649.
  • ^ Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999). "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British Journal of Pharmacology. 126 (7): 1575–84. doi:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589.
  • ^ Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG (October 1999). "Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors". British Journal of Pharmacology. 128 (3): 735–43. doi:10.1038/sj.bjp.0702836. PMC 1571677. PMID 10516656.
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