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Contents

   



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1 References  




2 External links  




3 Further reading  













ACVR1C






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From Wikipedia, the free encyclopedia
  
(Redirected from ALK7)
ACVR1C
Identifiers
AliasesACVR1C, ACVRLK7, ALK7, activin A receptor type 1C
External IDsOMIM: 608981; MGI: 2661081; HomoloGene: 26724; GeneCards: ACVR1C; OMA:ACVR1C - orthologs
Orthologs
SpeciesHumanMouse
Entrez

130399

269275

Ensembl

ENSG00000123612

ENSMUSG00000026834

UniProt

Q8NER5

Q8K348

RefSeq (mRNA)

NM_145259
NM_001111031
NM_001111032
NM_001111033

NM_001033369
NM_001111030

RefSeq (protein)

NP_001104501
NP_001104502
NP_001104503
NP_660302

NP_001028541
NP_001104500

Location (UCSC)Chr 2: 157.53 – 157.63 MbChr 2: 58.16 – 58.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The activin A receptor also known as ACVR1CorALK-7 is a protein that in humans is encoded by the ACVR1C gene.[5] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[5]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2orSMAD3.[6]

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123612 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026834 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ a b c Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62. doi:10.1159/000059339. PMID 12063393. S2CID 30962803.
  • ^ Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. doi:10.1124/mol.62.1.65. PMID 12065756. S2CID 15185199.

    • External links[edit]

    Further reading[edit]

  • Reissmann E, Jörnvall H, Blokzijl A, et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15): 2010–22. doi:10.1101/gad.201801. PMC 312747. PMID 11485994.
  • Andersson O, Korach-Andre M, Reissmann E, et al. (2008). "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity". Proc. Natl. Acad. Sci. U.S.A. 105 (20): 7252–6. Bibcode:2008PNAS..105.7252A. doi:10.1073/pnas.0800272105. PMC 2438236. PMID 18480259.
  • Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells". Biochem. Biophys. Res. Commun. 377 (3): 867–72. doi:10.1016/j.bbrc.2008.10.074. PMID 18951876.
  • Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID 12606401.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Xu G, Zhong Y, Munir S, et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7". J. Clin. Endocrinol. Metab. 89 (11): 5523–34. doi:10.1210/jc.2004-0893. PMID 15531507.
  • Xu G, Bernaudo S, Fu G, et al. (2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7". Mol. Biol. Cell. 19 (11): 4968–79. doi:10.1091/mbc.E08-03-0259. PMC 2575152. PMID 18784254.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim BC, van Gelder H, Kim TA, et al. (2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells" (PDF). J. Biol. Chem. 279 (27): 28458–65. doi:10.1074/jbc.M313277200. PMID 15107418. S2CID 29027775.
  • Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID 15150278.
  • Xu G, Zhou H, Wang Q, et al. (2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines". Mol. Cancer Res. 4 (4): 235–46. doi:10.1158/1541-7786.MCR-05-0174. PMID 16603637.
  • Tsuchida K, Nakatani M, Yamakawa N, et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1–2): 59–65. doi:10.1016/j.mce.2004.03.009. PMID 15196700. S2CID 25170545.

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