Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.
It is a tumor suppressor gene.[5]
This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler–Weber–Rendu syndrome, and the development of various types of tumors. At least 73 disease-causing mutations in this gene have been discovered.[6] Alternatively spliced transcript variants encoding different isoforms have been characterized.[7]
TGF beta receptor 2 has been shown to interact with:
Transforming growth factor beta receptor 2 ectodomain | |||||||||
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crystal structure of human tgf-beta type ii receptor ligand binding domain
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Identifiers | |||||||||
Symbol | ecTbetaR2 | ||||||||
Pfam | PF08917 | ||||||||
InterPro | IPR015013 | ||||||||
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TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).[18]
PDB gallery
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1ktz: Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3
1m9z: CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN
1plo: TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAIN
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Chemokine receptor (GPCRs) |
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TNF receptor |
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JAK-STAT |
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Ig superfamily |
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IL 17 family |
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Enzyme-linked receptor |
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Type I cytokine receptor |
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Receptor protein serine/threonine kinase |
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Receptor tyrosine kinase |
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Tumor necrosis factor receptor |
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Ig superfamily |
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Other/ungrouped |
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Type I |
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Type II |
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Type III |
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Unsorted |
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Ligand |
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Receptor |
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Intracellular signaling P+Ps |
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Nucleus |
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Mitochondrion |
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Other/ungrouped |
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