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Contents

   



(Top)
  


1 Function  




2 Interactions  




3 See also  




4 References  




5 Further reading  




6 External links  













CAMK2G






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From Wikipedia, the free encyclopedia
  

CAMK2G

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes

2UX0, 2V7O

Identifiers

Aliases

CAMK2G, CAMK, CAMK-II, CAMKG, calcium/calmodulin dependent protein kinase II gamma

External IDs

OMIM: 602123; MGI: 88259; HomoloGene: 15596; GeneCards: CAMK2G; OMA:CAMK2G - orthologs

Gene location (Human)

Chromosome 10 (human)

Chr.

Chromosome 10 (human)[1]

Chromosome 10 (human)

Genomic location for CAMK2G

Genomic location for CAMK2G

Band

10q22.2

Start

73,812,501 bp[1]

End

73,874,591 bp[1]

Gene location (Mouse)

Chromosome 14 (mouse)

Chr.

Chromosome 14 (mouse)[2]

Chromosome 14 (mouse)

Genomic location for CAMK2G

Genomic location for CAMK2G

Band

14|14 A3

Start

20,734,875 bp[2]

End

20,794,088 bp[2]

Bgee

Mouse (ortholog)

  • frontal pole

  • postcentral gyrus

  • right frontal lobe

  • popliteal artery

  • tibial arteries

  • Brodmann area 10

  • muscle layer of sigmoid colon

  • right coronary artery

  • lateral nuclear group of thalamus

  • primary visual cortex
    • zygote

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • secondary oocyte

  • central gray substance of midbrain

  • muscle of thigh

  • triceps brachii muscle

  • primary motor cortex

  • pontine nuclei

    • More reference expression data

    BioGPS



    More reference expression data

    Molecular function

  • nucleotide binding
  • protein kinase activity
  • protein homodimerization activity
  • kinase activity
  • protein binding
  • calcium-dependent protein serine/threonine phosphatase activity
  • ATP binding
  • protein serine/threonine kinase activity
  • calmodulin-dependent protein kinase activity
  • calmodulin binding
  • identical protein binding

    • Cellular component

  • cytosol
  • membrane
  • plasma membrane
  • nucleoplasm
  • sarcoplasmic reticulum
  • sarcoplasmic reticulum membrane
  • cytoplasm
  • postsynaptic density
  • neuron projection

    • Biological process

  • phosphorylation
  • interferon-gamma-mediated signaling pathway
  • G1 phase
  • regulation of relaxation of cardiac muscle
  • insulin secretion
  • MAPK cascade
  • multicellular organism development
  • protein phosphorylation
  • protein complex oligomerization
  • regulation of cellular response to heat
  • protein autophosphorylation
  • regulation of skeletal muscle adaptation
  • calcium ion transport
  • protein dephosphorylation
  • nervous system development
  • peptidyl-serine phosphorylation
  • peptidyl-threonine phosphorylation
  • cell differentiation
  • intracellular signal transduction
  • regulation of molecular function

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    818

    12325

    Ensembl

    ENSG00000148660

    ENSMUSG00000021820

    UniProt

    Q13555

    Q923T9

    RefSeq (mRNA)

    NM_172172
    NM_172173
    NM_001320898

    NM_001039138
    NM_001039139
    NM_178597
    NM_001360186

    RefSeq (protein)

    NP_751911
    NP_751913
    NP_001354443
    NP_001354445
    NP_001354446
    NP_001354447
    NP_001354448
    NP_001354449
    NP_001354450
    NP_001354451
    NP_001354452
    NP_001354453
    NP_001354454
    NP_001354455
    NP_001354456
    NP_001354457
    NP_001354458
    NP_001354459
    NP_001354460
    NP_001354461
    NP_001354462
    NP_001354463
    NP_001354464
    NP_001354465
    NP_001354466
    NP_001354467
    NP_001354468
    NP_001354469
    NP_001354470
    NP_001354471
    NP_001354472
    NP_001354473
    NP_001354474
    NP_001354475
    NP_001354476
    NP_001354477

    NP_001034227
    NP_001034228
    NP_848712
    NP_001347115

    Location (UCSC)

    Chr 10: 73.81 – 73.87 Mb

    Chr 14: 20.73 – 20.79 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.[5]

    Function[edit]

    The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.[6]

    Interactions[edit]

    CAMK2G has been shown to interact with RRAD.[7]

    See also[edit]

    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148660 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021820 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Li X, Nghiem P, Schulman H, Francke U (Feb 1994). "Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14". Cytogenet Cell Genet. 66 (2): 113–6. doi:10.1159/000133679. PMID 8287681. S2CID 46836396.
  • ^ "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma".
  • ^ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.

    • Further reading[edit]

  • Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso. 47 (3): 241–7. PMID 11889801.
  • Countaway JL, Nairn AC, Davis RJ (1992). "Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase". J. Biol. Chem. 267 (2): 1129–40. doi:10.1016/S0021-9258(18)48406-2. PMID 1309762.
  • Ikebe M, Reardon S (1990). "Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase". J. Biol. Chem. 265 (16): 8975–8. doi:10.1016/S0021-9258(19)38796-4. PMID 2160950.
  • Czernik AJ, Pang DT, Greengard P (1987). "Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I." Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7518–22. Bibcode:1987PNAS...84.7518C. doi:10.1073/pnas.84.21.7518. PMC 299327. PMID 3118371.
  • Vulliet PR, Woodgett JR, Cohen P (1984). "Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase". J. Biol. Chem. 259 (22): 13680–3. doi:10.1016/S0021-9258(18)89798-8. PMID 6150037.
  • Wen Z, Zhong Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2): 241–50. doi:10.1016/0092-8674(95)90311-9. PMID 7543024. S2CID 6717533.
  • Kwiatkowski AP, McGill JM (1995). "Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II". Gastroenterology. 109 (4): 1316–23. doi:10.1016/0016-5085(95)90594-4. PMID 7557101.
  • Shuai K, Stark GR, Kerr IM, Darnell JE (1993). "A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma". Science. 261 (5129): 1744–6. Bibcode:1993Sci...261.1744S. doi:10.1126/science.7690989. PMID 7690989.
  • Zhu J, Reynet C, Caldwell JS, Kahn CR (1995). "Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity". J. Biol. Chem. 270 (9): 4805–12. doi:10.1074/jbc.270.9.4805. PMID 7876254.
  • Yakel JL, Vissavajjhala P, Derkach VA, Brickey DA, Soderling TR (1995). "Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1376–80. Bibcode:1995PNAS...92.1376Y. doi:10.1073/pnas.92.5.1376. PMC 42522. PMID 7877986.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G (1993). "Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase". Biochim. Biophys. Acta. 1175 (2): 193–206. doi:10.1016/0167-4889(93)90023-I. PMID 8380342.
  • de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P (1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". EMBO J. 12 (10): 3903–11. doi:10.1002/j.1460-2075.1993.tb06068.x. PMC 413673. PMID 8404858.
  • Nghiem P, Saati SM, Martens CL, Gardner P, Schulman H (1993). "Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues". J. Biol. Chem. 268 (8): 5471–9. doi:10.1016/S0021-9258(18)53345-7. PMID 8449910.
  • Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". J. Biol. Chem. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317.
  • Wei J, Wayman G, Storm DR (1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". J. Biol. Chem. 271 (39): 24231–5. doi:10.1074/jbc.271.39.24231. PMID 8798667.
  • Tombes RM, Krystal GW (1997). "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta. 1355 (3): 281–92. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999.
  • Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.

    • External links[edit]


    • 2ux0: STRUCTURE OF THE OLIGOMERISATION DOMAIN OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II GAMMA
    2ux0: STRUCTURE OF THE OLIGOMERISATION DOMAIN OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II GAMMA

    Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

  • LATS2
  • MAST1
  • MAST2
  • STK38
  • STK38L
  • CIT
  • ROCK1
  • SGK
  • SGK2
  • SGK3
  • Protein kinase B
  • Ataxia telangiectasia mutated
  • mTOR
  • EIF-2 kinases
  • Wee1

    • Pyruvate dehydrogenase kinase (EC 2.7.11.2)

  • PDK2
  • PDK3
  • PDK4

    • Dephospho-(reductase kinase) kinase (EC 2.7.11.3)

  • PRKAA2
  • β
  • γ

    • 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)

  • BCKDHA
  • BCKDHB

    • (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)

  • IDH3A
  • IDH3B
  • IDH3G

    • (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)

    Myosin-heavy-chain kinase (EC 2.7.11.7)

  • Aurora B kinase
  • Aurora C kinase

    • Fas-activated serine/threonine kinase (EC 2.7.11.8)

  • STK10

    • Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)

    • -

    IκB kinase (EC 2.7.11.10)

  • IKK2
  • TBK1
  • IKBKE
  • IKBKG
  • IKBKAP

    • cAMP-dependent protein kinase (EC 2.7.11.11)

  • PRKACG
  • PRKACB
  • PRKACA
  • PRKY

    • cGMP-dependent protein kinase (EC 2.7.11.12)

  • PRKG1

    • Protein kinase C (EC 2.7.11.13)

  • Protein kinase Cζ
  • PKC alpha
  • PRKCB1
  • PRKCD
  • PRKCE
  • PRKCH
  • PRKCG
  • PRKCI
  • PRKCQ
  • Protein kinase N1
  • PKN2
  • PKN3

    • Rhodopsin kinase (EC 2.7.11.14)

    Beta adrenergic receptor kinase (EC 2.7.11.15)

  • Beta adrenergic receptor kinase-2

    • G-protein coupled receptor kinases (EC 2.7.11.16)

  • GRK5
  • GRK6

    • Ca2+/calmodulin-dependent (EC 2.7.11.17)

  • CAMK1
  • CAMK1A
  • CAMK1B
  • CAMK1D
  • CAMK1G
  • CAMK2
  • CAMK2A
  • CAMK2B
  • CAMK2D
  • CAMK2G
  • CAMK4
  • MLCK
  • CASK
  • CHEK1
  • CHEK2
  • DAPK1
  • DAPK2
  • DAPK3
  • STK11
  • MAPKAPK2
  • MAPKAPK3
  • MAPKAPK5
  • MARK1
  • MARK2
  • MARK3
  • MARK4
  • MELK
  • MKNK1
  • MKNK2
  • NUAK1
  • NUAK2
  • OBSCN
  • PASK
  • PHKG1
  • PHKG2
  • PIM1
  • PIM2
  • PKD1
  • PRKD2
  • PRKD3
  • PSKH1
  • SNF1LK2
  • KIAA0999
  • STK40
  • SNF1LK
  • SNRK
  • SPEG
  • TSSK2
  • Kalirin
  • TRIB1
  • TRIB2
  • TRIB3
  • TRIO
  • Titin
  • DCLK1

    • Myosin light-chain kinase (EC 2.7.11.18)

  • MYLK2
  • MYLK3
  • MYLK4

    • Phosphorylase kinase (EC 2.7.11.19)

  • PHKA2
  • PHKB
  • PHKG1
  • PHKG2

    • Elongation factor 2 kinase (EC 2.7.11.20)

  • STK19

    • Polo kinase (EC 2.7.11.21)

  • PLK2
  • PLK3
  • PLK4

    • Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

    Polo kinase (EC 2.7.11.21)

  • PLK2
  • PLK3
  • PLK4

    • Cyclin-dependent kinase (EC 2.7.11.22)

  • CDK2
  • CDKL2
  • CDK3
  • CDK4
  • CDK5
  • CDKL5
  • CDK6
  • CDK7
  • CDK8
  • CDK9
  • CDK10
  • CDK12
  • CDC2L5
  • PCTK1
  • PCTK2
  • PCTK3
  • PFTK1
  • CDC2L1

    • (RNA-polymerase)-subunit kinase (EC 2.7.11.23)

  • RPS6KA4
  • P70S6 kinase
  • P70-S6 Kinase 1
  • RPS6KB2
  • RPS6KA2
  • RPS6KA3
  • RPS6KA1
  • RPS6KC1

    • Mitogen-activated protein kinase (EC 2.7.11.24)

  • MAPK3
  • MAPK4
  • MAPK6
  • MAPK7
  • MAPK12
  • MAPK15
  • C-Jun N-terminal
  • P38 mitogen-activated protein

    • MAP3K (EC 2.7.11.25)

  • MAP3K2
  • MAP3K3
  • MAP3K4
  • MAP3K5
  • MAP3K6
  • MAP3K7
  • MAP3K8
  • RAFs
  • MLKs
  • CDC7
  • MAP3K14

    • Tau-protein kinase (EC 2.7.11.26)

  • TTK
  • GSK-3

    • (acetyl-CoA carboxylase) kinase (EC 2.7.11.27)

    • -

    Tropomyosin kinase (EC 2.7.11.28)

    • -

    Low-density-lipoprotein receptor kinase (EC 2.7.11.29)

    • -

    Receptor protein serine/threonine kinase (EC 2.7.11.30)

  • BMPR1A
  • BMPR1B
  • BMPR2
  • ACVR1
  • ACVR1B
  • ACVR1C
  • ACVR2A
  • ACVR2B
  • ACVRL1
  • Anti-Müllerian hormone receptor

  • MAP2K2
  • MAP2K3
  • MAP2K4
  • MAP2K5
  • MAP2K6
  • MAP2K7

    • Activity

  • Binding site
  • Catalytic triad
  • Oxyanion hole
  • Enzyme promiscuity
  • Diffusion-limited enzyme
  • Cofactor
  • Enzyme catalysis

    • Regulation

  • Cooperativity
  • Enzyme inhibitor
  • Enzyme activator

    • Classification

  • Enzyme superfamily
  • Enzyme family
  • List of enzymes

    • Kinetics

  • Eadie–Hofstee diagram
  • Hanes–Woolf plot
  • Lineweaver–Burk plot
  • Michaelis–Menten kinetics

    • Types

  • EC2 Transferases (list)
  • EC3 Hydrolases (list)
  • EC4 Lyases (list)
  • EC5 Isomerases (list)
  • EC6 Ligases (list)
  • EC7 Translocases (list)

    • This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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