J u m p t o c o n t e n t
M a i n m e n u
M a i n m e n u
N a v i g a t i o n
● M a i n p a g e ● C o n t e n t s ● C u r r e n t e v e n t s ● R a n d o m a r t i c l e ● A b o u t W i k i p e d i a ● C o n t a c t u s ● D o n a t e
C o n t r i b u t e
● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t ● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t ● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 I n t e r a c t i o n s
2 R e f e r e n c e s
3 F u r t h e r r e a d i n g
T o g g l e t h e t a b l e o f c o n t e n t s
R P S 6 K A 2
3 l a n g u a g e s
● E s p a ñ o l ● Т а т а р ч а / t a t a r ç a ● У к р а ї н с ь к а
E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
● R e a d ● E d i t ● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d ● E d i t ● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e ● R e l a t e d c h a n g e s ● U p l o a d f i l e ● S p e c i a l p a g e s ● P e r m a n e n t l i n k ● P a g e i n f o r m a t i o n ● C i t e t h i s p a g e ● G e t s h o r t e n e d U R L ● D o w n l o a d Q R c o d e ● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
RPS6KA2
OMIM : 601685 ; MGI : 1342290 ; HomoloGene : 100680 ; GeneCards : RPS6KA2 ; OMA :RPS6KA2 - orthologs
Chromosome 6 (human) [1]
6q27
Start
166,409,364 bp [1]
166,906,451 bp [1]
Chromosome 17 (mouse)[2]
17 A1|17 4.7 cM
Start
7,437,514 bp [2]
7,570,714 bp [2]
dorsal motor nucleus of vagus nerve
inferior ganglion of vagus nerve
C1 segment
optic nerve
right lung
corpus callosum
superior vestibular nucleus
superior frontal gyrus
dentate gyrus of hippocampal formation granule cell
primary visual cortex
genital tubercle
lens
ventricular zone
protein binding
protein serine/threonine/tyrosine kinase activity
ATP binding
magnesium ion binding
kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
nucleoplasm
nucleus
protein phosphorylation
positive regulation of apoptotic process
negative regulation of cell population proliferation
signal transduction
intracellular signal transduction
Chr 6: 166.41 – 166.91 Mb
Chr 17: 7.44 – 7.57 Mb
[3]
[4]
Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene .[5] [6]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases . This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen -activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation . Alternate transcriptional splice variants, encoding different isoforms , have been characterized.[6]
Interactions [ edit ]
RPS6KA2 has been shown to interact with MAPK3 [7] [8] MAPK1 .[7] [8]
References [ edit ]
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 .
^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2" .
^ a b Roux PP, Richards Stephanie A, Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity" . Mol. Cell. Biol . 23 14 ). United States: 4796–804. doi :10.1128/MCB.23.14.4796-4804.2003 . ISSN 0270-7306 . PMC 162206 PMID 12832467 .
^ a b Zhao Y, Bjorbaek C, Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47 ). UNITED STATES: 29773–9. doi :10.1074/jbc.271.47.29773 ISSN 0021-9258 . PMID 8939914 .
Further reading [ edit ]
Zhao Y, Bjørbaek C, Weremowicz S, et al. (1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation" . Mol. Cell. Biol . 15 8 ): 4353–63. doi :10.1128/MCB.15.8.4353 . PMC 230675 PMID 7623830 .
Wong EV, Schaefer AW, Landreth G, Lemmon V (1996). "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1" . J. Biol. Chem . 271 (30 ): 18217–23. doi :10.1074/jbc.271.30.18217 PMID 8663493 .
Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–63. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 .
Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47 ): 29773–9. doi :10.1074/jbc.271.47.29773 PMID 8939914 .
Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates" . EMBO J . 16 8 ): 1921–33. doi :10.1093/emboj/16.8.1921 . PMC 1169795 PMID 9155018 .
del Peso L, González-García M, Page C, et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science . 278 (5338): 687–9. Bibcode :1997Sci...278..687D . doi :10.1126/science.278.5338.687 . PMID 9381178 .
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 15 ): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 .
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB" . J. Biol. Chem . 273 (49 ): 32377–9. doi :10.1074/jbc.273.49.32377 PMID 9829964 .
Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . J. Biol. Chem . 274 (5 ): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 .
Jensen CJ, Buch MB, Krag TO, et al. (1999). "90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1" . J. Biol. Chem . 274 (38 ): 27168–76. doi :10.1074/jbc.274.38.27168 PMID 10480933 .
Schimenti JC (2000). "ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus". Mamm. Genome . 10 10 ): 969–76. doi :10.1007/s003359901142 . PMID 10501965 . S2CID 23157540 .
Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L ) by the MAPK/Erk kinase" . J. Biol. Chem . 274 (43 ): 31108–13. doi :10.1074/jbc.274.43.31108 PMID 10521512 .
Tan Y, Demeter MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival" . J. Biol. Chem . 275 (33 ): 25865–9. doi :10.1074/jbc.M004199200 PMID 10837486 .
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155" . Biochem. J . 349 (Pt 2): 547–57. doi :10.1042/0264-6021:3490547 . PMC 1221178 PMID 10880354 .
Datta SR, Katsov A, Hu L, et al. (2000). "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation" . Mol. Cell . 6 1 ): 41–51. doi :10.1016/S1097-2765(00 )00006-X PMID 10949026 .
Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene . 19 54 ): 6324–33. doi :10.1038/sj.onc.1204007 . PMID 11175347 . S2CID 20150481 .
Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit". Cell. Signal . 13 9 ): 653–64. doi :10.1016/S0898-6568(01 )00185-1 . PMID 11495723 .
Schinelli S, Zanassi P, Paolillo M, et al. (2001). "Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways" . J. Neurosci . 21 22 ): 8842–53. doi :10.1523/JNEUROSCI.21-22-08842.2001 . PMC 6762276 PMID 11698596 .
STK38
STK38L
CIT
ROCK1
SGK
SGK2
SGK3
Protein kinase B
Ataxia telangiectasia mutated
mTOR
EIF-2 kinases
Wee1
PDK2
PDK3
PDK4
PRKAA2
β
γ
BCKDHA
BCKDHB
IDH3A
IDH3B
IDH3G
Aurora B kinase
Aurora C kinase
STK10
IKK2
TBK1
IKBKE
IKBKG
IKBKAP
PRKACG
PRKACB
PRKACA
PRKY
PRKG1
Protein kinase Cζ
PKC alpha
PRKCB1
PRKCD
PRKCE
PRKCH
PRKCG
PRKCI
PRKCQ
Protein kinase N1
PKN2
PKN3
Beta adrenergic receptor kinase-2
GRK5
GRK6
CAMK1
CAMK1A
CAMK1B
CAMK1D
CAMK1G
CAMK2
CAMK2A
CAMK2B
CAMK2D
CAMK2G
CAMK4
MLCK
CASK
CHEK1
CHEK2
DAPK1
DAPK2
DAPK3
STK11
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MELK
MKNK1
MKNK2
NUAK1
NUAK2
OBSCN
PASK
PHKG1
PHKG2
PIM1
PIM2
PKD1
PRKD2
PRKD3
PSKH1
SNF1LK2
KIAA0999
STK40
SNF1LK
SNRK
SPEG
TSSK2
Kalirin
TRIB1
TRIB2
TRIB3
TRIO
Titin
DCLK1
MYLK2
MYLK3
MYLK4
PHKA2
PHKB
PHKG1
PHKG2
STK19
PLK2
PLK3
PLK4
CDK2
CDKL2
CDK3
CDK4
CDK5
CDKL5
CDK6
CDK7
CDK8
CDK9
CDK10
CDK12
CDC2L5
PCTK1
PCTK2
PCTK3
PFTK1
CDC2L1
RPS6KA4
P70S6 kinase
P70-S6 Kinase 1
RPS6KB2
RPS6KA2
RPS6KA3
RPS6KA1
RPS6KC1
MAPK3
MAPK4
MAPK6
MAPK7
MAPK12
MAPK15
C-Jun N-terminal
P38 mitogen-activated protein
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP3K6
MAP3K7
MAP3K8
RAFs
MLKs
CDC7
MAP3K14
TTK
GSK-3
BMPR1A
BMPR1B
BMPR2
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
ACVRL1
Anti-Müllerian hormone receptor
MAP2K5
MAP2K6
MAP2K7
Binding site
Catalytic triad
Oxyanion hole
Enzyme promiscuity
Diffusion-limited enzyme
Cofactor
Enzyme catalysis
Cooperativity
Enzyme inhibitor
Enzyme activator
Enzyme superfamily
Enzyme family
List of enzymes
Eadie–Hofstee diagram
Hanes–Woolf plot
Lineweaver–Burk plot
Michaelis–Menten kinetics
EC2 Transferases (list )
EC3 Hydrolases (list )
EC4 Lyases (list )
EC5 Isomerases (list )
EC6 Ligases (list )
EC7 Translocases (list )
t
e
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=RPS6KA2&oldid=1191466215 " C a t e g o r i e s : ● G e n e s o n h u m a n c h r o m o s o m e 6 ● E C 2 . 7 . 1 1 ● H u m a n c h r o m o s o m e 6 g e n e s t u b s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 3 D e c e m b e r 2 0 2 3 , a t 1 8 : 5 3 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
