TRIB2
Identifiers
TRIB2, C5FW, GS3955, TRB2, tribbles pseudokinase 2
External IDs
OMIM: 609462; MGI: 2145021; HomoloGene: 41445; GeneCards: TRIB2; OMA:TRIB2 - orthologs
Gene location (Human)
2p24.3
Start
End
Gene location (Mouse)
Chromosome 12 (mouse)[2]
12|12 A1.1
Start
End
Molecular function
Cellular component
Biological process
Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene.[5][6][7][8] TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing very low vestigial catalytic output in vitro and critical scaffolding signaling functions in cells.[9] It is known to signal to canonical MAPK and AKT pathways and to regulate the ubiquitination of substrates with important functions in cell proliferation that control the cell ccyle. It has also been associated with various diseases, especially in human and murine blood and solid tumor models.[10] Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target,[11] and its three dimensional structure has been solved with the aid of stabilizing nanobodies [12] corroborating the potential for new approaches for drug targeting outside the highly degraded ATP site [13] and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation.[14] Recent work has established a convincing link between targetable overexpression of TRIB2 and prostate cancer drug responses [15]
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
Tropomyosin kinase (EC 2.7.11.28)
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
Receptor protein serine/threonine kinase (EC 2.7.11.30)
Activity
Regulation
Classification
Kinetics
Types