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PCTK3

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CDK18

Identifiers

Aliases

CDK18, PCTAIRE, PCTAIRE3, PCTK3, cyclin-dependent kinase 18, cyclin dependent kinase 18

External IDs

OMIM: 169190; MGI: 97518; HomoloGene: 1949; GeneCards: CDK18; OMA:CDK18 - orthologs

Gene location (Human)

Chr.

Chromosome 1 (human)^[1]

Band

1q32.1

Start

205,504,596 bp^[1]

End

205,532,793 bp^[1]

Gene location (Mouse)

Chr.

Chromosome 1 (mouse)^[2]

Band

1|1 E4

Start

132,039,975 bp^[2]

End

132,067,422 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

C1 segment

inferior ganglion of vagus nerve

apex of heart

middle frontal gyrus

subthalamic nucleus

right auricle

corpus callosum

pars reticulata

left ventricle

ventral tegmental area

Top expressed in

duodenum

molar

right kidney

jejunum

pontine nuclei

lumbar subsegment of spinal cord

epithelium of stomach

transitional epithelium of urinary bladder

intestinal villus

dorsomedial hypothalamic nucleus

More reference expression data

BioGPS

More reference expression data

Gene ontology

Molecular function

transferase activity

nucleotide binding

protein kinase activity

protein binding

ATP binding

kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein serine/threonine kinase activity

Cellular component

nucleus

cytoplasm

cellular component

Biological process

phosphorylation

protein phosphorylation

regulation of cell cycle

Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

NM_002596
NM_212502
NM_212503

NM_008795

RefSeq (protein)

NP_002587
NP_997667
NP_997668

NP_032821

Location (UCSC)

Chr 1: 205.5 – 205.53 Mb

Chr 1: 132.04 – 132.07 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the CDK18 gene.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117266 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026437 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.

^ "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Further reading[edit]

Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.

Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain". Gene. 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195. S2CID 39038607.