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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
RPS6KA3
OMIM : 300075 ; MGI : 104557 ; HomoloGene : 37940 ; GeneCards : RPS6KA3 ; OMA :RPS6KA3 - orthologs
X chromosome (human) [1]
Xp22.12
Start
20,149,911 bp [1]
20,267,519 bp [1]
X chromosome (mouse)[2]
X F4|X 73.27 cM
Start
157,993,303 bp [2]
158,151,240 bp [2]
glutes
quadriceps femoris muscle
Skeletal muscle tissue of biceps brachii
lumbar spinal ganglion
Paneth cell
left lung lobe
genital tubercle
mandibular prominence
gastrula
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein binding
ATP binding
protein kinase binding
magnesium ion binding
kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
nucleoplasm
nucleus
regulation of translation in response to stress
intracellular signal transduction
phosphorylation
negative regulation of apoptotic process
protein phosphorylation
central nervous system development
positive regulation of cell growth
response to lipopolysaccharide
positive regulation of cell differentiation
cell cycle
regulation of DNA-templated transcription in response to stress
signal transduction
positive regulation of transcription by RNA polymerase II
toll-like receptor signaling pathway
apoptotic process
peptidyl-serine phosphorylation
Chr X: 20.15 – 20.27 Mb
Chr X: 157.99 – 158.15 Mb
[3]
[4]
protein S6 kinase, 90kDa, polypeptide 3 , also s RPS6KA3 , is an enzyme that in humans is encoded by the RPS6KA3 gene .[5] [6]
Function [ edit ]
This gene encodes a member of the RSK (ribosomal S6 kinase ) family of serine/threonine kinases . This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway . The activity of this protein has been implicated in controlling cell growth and differentiation.[5]
Clinical significance [ edit ]
Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).[7]
Interactions [ edit ]
RPS6KA3 has been shown to interact with CREB-binding protein ,[8] MAPK1 [9] [10] PEA15 .[11]
References [ edit ]
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b "Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3" .
^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression" . The American Journal of Physiology . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 .
^ Jacquot S, Zeniou M, Touraine R, Hanauer A (January 2002). "X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1)" . European Journal of Human Genetics . 10 1 ): 2–5. doi :10.1038/sj.ejhg.5200738 PMID 11896450 .
^ Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P (October 2001). "Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities" . Molecular and Cellular Biology . 21 20 ): 7089–96. doi :10.1128/MCB.21.20.7089-7096.2001 . PMC 99884 PMID 11564891 .
^ Zhao Y, Bjorbaek C, Moller DE (November 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . The Journal of Biological Chemistry . 271 (47 ): 29773–9. doi :10.1074/jbc.271.47.29773 PMID 8939914 .
^ Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . The Journal of Biological Chemistry . 274 (5 ): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 .
^ Vaidyanathan H, Ramos JW (August 2003). "RSK2 activity is regulated by its interaction with PEA-15" . The Journal of Biological Chemistry . 278 (34 ): 32367–72. doi :10.1074/jbc.M303988200 PMID 12796492 .
Further reading [ edit ]
Ku NO, Omary MB (October 1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization" . The Journal of Cell Biology . 127 (1 ): 161–71. doi :10.1083/jcb.127.1.161 . PMC 2120194 PMID 7523419 .
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 .
Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE (August 1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation" . Molecular and Cellular Biology . 15 8 ): 4353–63. doi :10.1128/MCB.15.8.4353 . PMC 230675 PMID 7623830 .
Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL (January 1995). "Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients". Diabetes . 44 1 ): 90–7. doi :10.2337/diabetes.44.1.90 . PMID 7813820 .
Donnelly AJ, Choo KH, Kozman HM, Gedeon AK, Danks DM, Mulley JC (July 1994). "Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22". American Journal of Medical Genetics . 51 4 ): 581–5. doi :10.1002/ajmg.1320510457 . PMID 7943043 .
Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 .
Xing J, Ginty DD, Greenberg ME (August 1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–63. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 .
Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A (December 1996). "Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome". Nature . 384 (6609): 567–70. Bibcode :1996Natur.384..567T . doi :10.1038/384567a0 . PMID 8955270 . S2CID 4242547 .
Paudel HK (November 1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro" . The Journal of Biological Chemistry . 272 (45 ): 28328–34. doi :10.1074/jbc.272.45.28328 PMID 9353289 .
Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA (April 1998). "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167" . Molecular and Cellular Biology . 18 4 ): 1978–84. doi :10.1128/mcb.18.4.1978 . PMC 121427 PMID 9528769 .
Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, Illenberger S, Godemann R, Mandelkow E (March 1998). "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation" . European Journal of Biochemistry . 252 (3 ): 542–52. doi :10.1046/j.1432-1327.1998.2520542.x PMID 9546672 .
Deak M, Clifton AD, Lucocq LM, Alessi DR (August 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . The EMBO Journal . 17 15 ): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 .
Du K, Montminy M (December 1998). "CREB is a regulatory target for the protein kinase Akt/PKB" . The Journal of Biological Chemistry . 273 (49 ): 32377–9. doi :10.1074/jbc.273.49.32377 PMID 9829964 .
Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH (December 1998). "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry" . Journal of Neurochemistry . 71 6 ): 2465–76. doi :10.1046/j.1471-4159.1998.71062465.x PMID 9832145 .
Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel JL, Sassone-Corsi P, Hanauer A (December 1998). "Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations" . American Journal of Human Genetics . 63 6 ): 1631–40. doi :10.1086/302153 . PMC 1377634 PMID 9837815 .
Jacquot S, Merienne K, Pannetier S, Blumenfeld S, Schinzel A, Hanauer A (1999). "Germline mosaicism in Coffin-Lowry syndrome" . European Journal of Human Genetics . 6 6 ): 578–82. doi :10.1038/sj.ejhg.5200230 PMID 9887375 .
Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . The Journal of Biological Chemistry . 274 (5 ): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 .
Abidi F, Jacquot S, Lassiter C, Trivier E, Hanauer A, Schwartz CE (January 1999). "Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS)" . European Journal of Human Genetics . 7 1 ): 20–6. doi :10.1038/sj.ejhg.5200231 PMID 10094187 .
Merienne K, Jacquot S, Pannetier S, Zeniou M, Bankier A, Gecz J, Mandel JL, Mulley J, Sassone-Corsi P, Hanauer A (May 1999). "A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation". Nature Genetics . 22 1 ): 13–4. doi :10.1038/8719 . PMID 10319851 . S2CID 30949315 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=RPS6KA3&oldid=1188159423 " C a t e g o r i e s : ● G e n e s o n h u m a n c h r o m o s o m e X ● E C 2 . 7 . 1 1 H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a
● T h i s p a g e w a s l a s t e d i t e d o n 3 D e c e m b e r 2 0 2 3 , a t 1 8 : 1 9 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
