Cytochrome P450, family 105, also known as CYP105, is a cytochrome P450 monooxygenase familyinbacteria, predominantly found in the phylum Actinomycetota and the order Actinomycetales.[2][3] The first three genes and subfamilies identified in this family is the herbicide-inducible P-450SU1 (CYP105A1, subfamily A) and P-450SU2 (CYP105B1, subfamily B) from Streptomyces griseolus[4][5] and choP (CYP105C1, subfamily C) from Streptomyces sp'scholesterol oxidase promoter region.[6][1]
| Subfamily[7] | first gene identified | Species | REF |
|---|---|---|---|
| A | SU1 (CYP105A1) | Streptomyces griseolus | [4] |
| B | SU2 (CYP105B1) | Streptomyces griseolus | [4] |
| C | choP (CYP105C1) | Streptomyces sp | [6] |
| D | soyC (CYP105D1) | Streptomyces griseus | [8] |
| E | ORF1 (CYP105E1) | Rhodococcus fascians | [9] |
CYP105 enzymes is widely used in industry, such as the production of pravastatin.[3]
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| |
|---|---|
| CYP1 |
|
| CYP2 |
|
| CYP3 (CYP3A) |
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| CYP4 |
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| CYP5-20 |
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| CYP21-49 |
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| CYP51-69 |
|
| CYP71-99 |
|
| CYP101-281 |
|
| CYP301-499 |
|
| CYP501-699 |
|
| CYP701-999 |
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