| Sterol 22-desaturase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | Saccharomyces cerevisiae S288c | ||||||
| Symbol | ERG5 | ||||||
| Alt. symbols | CYP61A1 | ||||||
| Entrez | 855029 | ||||||
| HomoloGene | 20212 | ||||||
| RefSeq (mRNA) | NM_001182511.1 | ||||||
| RefSeq (Prot) | NP_013728.1 | ||||||
| UniProt | P54781 | ||||||
| Other data | |||||||
| EC number | 1.14.19.41 | ||||||
| Chromosome | XIII: 0.3 - 0.3 Mb | ||||||
| |||||||
ERG5orSterol 22-desaturase is a cytochrome P450 enzyme in the ergosterol biosynthesis pathway of fungi Saccharomyces cerevisiae (Baker's yeast, a model organism), with the CYP Symbol CYP61A1.[1] CYP61A1 is one of only three P450 enzyme found in baker's yeast, the other two are CYP51F1 and CYP56A1.[2] The ortholog in Schizosaccharomyces pombe (fission yeast, the second sequenced model fungi), was named CYP61A3 for historical reasons, and is only one of two P450 enzyme found with CYP51F1.[3] ERG5 catalyzes the C22-C23 double bond formation on the sterol side chain of ergostatrienol to convert it into ergostatetraenol, then the C24 double bond of ergostatetrenol will be hydrogenation reduced into ergosterolbyERG4.[4]
Most fungi have only one CYP61 gene, and CYP61 global distributed in fungi.[5][6] There are some of the ortholog found in early genome sequenced organism:[7]
| CYP symbol | Species | UniProt/EMBL |
|---|---|---|
| CYP61A1 | Saccharomyces cerevisiae | P54781 |
| CYP61A2 | Candida albicans | A0A1B3B2L4 |
| CYP61A3 | Schizosaccharomyces pombe | O13820 |
| CYP61A4 | Botrytis cinerea | AL111744 |
| CYP61A5 | Neurospora crassa |
|
| |
|---|---|
| CYP1 |
|
| CYP2 |
|
| CYP3 (CYP3A) |
|
| CYP4 |
|
| CYP5-20 |
|
| CYP21-49 |
|
| CYP51-69 |
|
| CYP71-99 |
|
| CYP101-281 |
|
| CYP301-499 |
|
| CYP501-699 |
|
| CYP701-999 |
|
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