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EPHB6

Protein-coding gene in the species Homo sapiens

EPHB6
Identifiers
Aliases	EPHB6, HEP, EPH receptor B6
External IDs	OMIM: 602757; MGI: 1096338; HomoloGene: 20940; GeneCards: EPHB6; OMA:EPHB6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 142,855,061 bp[1] End 142,871,094 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.1 Start 41,582,416 bp[2] End 41,597,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus putamen caudate nucleus dorsolateral prefrontal cortex right frontal lobe anterior cingulate cortex skin of abdomen Brodmann area 9 prefrontal cortex Top expressed in lip primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell pleural cavity pericardium pericardial cavity skin of external ear prefrontal cortex thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity protein binding ATP binding ephrin receptor activity signaling receptor activity protein tyrosine kinase activity receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity transmembrane receptor protein tyrosine kinase activity Cellular component integral component of membrane extracellular region cytosol plasma membrane integral component of plasma membrane membrane cytoplasm neuron projection receptor complex Biological process protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway ephrin receptor signaling pathway peptidyl-tyrosine phosphorylation negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2051 13848 Ensembl ENSG00000106123 ENSG00000275482 ENSMUSG00000029869 UniProt O15197 O08644 RefSeq (mRNA) NM_001280794 NM_001280795 NM_004445 NM_001146351 NM_007680 RefSeq (protein) NP_001267723 NP_001267724 NP_004436 NP_001139823 NP_031706 Location (UCSC) Chr 7: 142.86 – 142.87 Mb Chr 6: 41.58 – 41.6 Mb PubMed search [3] [4]
Wikidata
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Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.^[5]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.^[5]

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