Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-Leu-, -Leu6-Cys-, -Ala14-Leu- and -Cys19-Gly- bonds in insulin B chain
Even though it is primarily found and embedded into the cell membrane it can also be found in the extracellular space.[5] Like other meprins it can hydrolyze different molecules.[5]
^Kounnas MZ, Wolz RL, Gorbea CM, Bond JS (September 1991). "Meprin-A and -B. Cell surface endopeptidases of the mouse kidney". The Journal of Biological Chemistry. 266 (26): 17350–7. PMID1894622.
^Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS (October 1993). "Cloning, expression, and chromosomal localization of the mouse meprin beta subunit". The Journal of Biological Chemistry. 268 (28): 21035–43. PMID8407940.
^Johnson GD, Hersh LB (March 1994). "Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation". The Journal of Biological Chemistry. 269 (10): 7682–8. PMID7510289.