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NNC 38-1049

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NNC 38-1049
Names

Preferred IUPAC name 1-(4-Chlorophenyl)-4-(4-cyclopentylpiperazin-1-yl)butane-1,4-dione
Identifiers
CAS Number	757183-18-9^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL97170^Y
ChemSpider	7974195^Y
PubChem CID	9798429
UNII	63G6TLD54V^Y
CompTox Dashboard (EPA)	DTXSID70430911
InChI InChI=1S/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2^Y Key: VPARRMQGLNFBBR-UHFFFAOYSA-N^Y InChI=1/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 Key: VPARRMQGLNFBBR-UHFFFAOYAT
SMILES Clc1ccc(cc1)C(=O)CCC(=O)N3CCN(C2CCCC2)CC3
Properties
Chemical formula	C₁₉H₂₅ClN₂O₂
Molar mass	348.866 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references

NNC 38-1049 is a histamine antagonist selective for the H₃ subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.^[1]^[2]

References[edit]

^ Malmlöf K, Zaragoza F, Golozoubova V, et al. (December 2005). "Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight". Int J Obes (Lond). 29 (12): 1402–12. doi:10.1038/sj.ijo.0803036. PMID 16151415.

^ Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K (Dec 2006). "Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides". Obesity (Silver Spring). 14 (12): 2154–62. doi:10.1038/oby.2006.252. PMID 17189541.

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Histamine receptor modulators

H₁

Agonists

Antagonists

Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)

H₂

Agonists

Antagonists

H₃

Agonists

Antagonists

H₄

Agonists

Antagonists

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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