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| Trade names | Ambodryl, Ambrodil, Deserol |
| Other names | Bromodiphenhydramine; Bromdiphenhydramine |
| MedlinePlus | a682065 |
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | High |
| Protein binding | 96% |
| Metabolism | Mostly hepatic (CYP-mediated), also renal |
| Elimination half-life | 1 to 4 hours |
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| ECHA InfoCard | 100.003.854  |
| Chemical and physical data | |
| Formula | C17H20BrNO |
| Molar mass | 334.257 g·mol−1 |
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Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an antihistamine and anticholinergic medication of the ethanolamine class.[1][2][3][4][5] It is an analogueofdiphenhydramine with a bromine substitution on one of the phenyl rings.[1][2]
Grignard reaction between phenylmagnesium bromide and para-bromobenzaldehyde [1122-91-4] (1) gives p-bromobenzhydrol [29334-16-5] (2). Halogenation with acetyl bromide in benzene solvent gives p-bromo-benzhydrylbromide [18066-89-2] (3). Finally, etherification with deanol completed the synthesis of Bromazine (4).
Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in elderly people.[8][9]
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