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1 See also  





2 References  














Phenoxypropazine






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From Wikipedia, the free encyclopedia
 


Phenoxypropazine
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (1-methyl-2-phenoxy-ethyl)hydrazine

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H14N2O
Molar mass166.224 g·mol−1

Phenoxypropazine (trade name Drazine) is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine family. It was introduced as an antidepressant in 1961, but was subsequently withdrawn in 1966 due to hepatotoxicity concerns.[1][2][3][4][5]

See also[edit]

References[edit]

  1. ^ LEAHY MR, ROSE JT, PLOWMAN R (April 1963). "A preliminary study of phenoxypropazine in the treatment of depression". The American Journal of Psychiatry. 119 (10): 986–7. doi:10.1176/ajp.119.10.986. PMID 13928824.
  • ^ IMLAH NW (May 1963). "Preliminary report on phenoxypropazine". The American Journal of Psychiatry. 119 (11): 1091–2. doi:10.1176/ajp.119.11.1091. PMID 13956423.
  • ^ ROSE JT, LEAHY MR, PLOWMAN R (October 1963). "A comparison of phenoxypropazine and amitriptyline in depression". The American Journal of Psychiatry. 120 (4): 393–5. doi:10.1176/ajp.120.4.393. PMID 14069469.
  • ^ ROSE JT (March 1964). "Phenoxypropazine and chlordiazepoxide in depression". The American Journal of Psychiatry. 120 (9): 899–900. doi:10.1176/ajp.120.9.899. PMID 14129290.
  • ^ MCWHINNEY IR, MORRELL DC (January 1965). "Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice". The Journal of the College of General Practitioners. 9 (1): 95–9. PMC 1878242. PMID 14254271.

  • t
  • e

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Phenoxypropazine&oldid=1144171123"

    Categories: 
    Drugs not assigned an ATC code
    Hepatotoxins
    Hydrazines
    Monoamine oxidase inhibitors
    Phenol ethers
    Withdrawn drugs
    Nervous system drug stubs
    Hidden categories: 
    Articles with short description
    Short description matches Wikidata
    Drugs with non-standard legal status
    Chemical pages without DrugBank identifier
    Articles without KEGG source
    Articles without InChI source
    Articles containing unverified chemical infoboxes
    All stub articles
     



    This page was last edited on 12 March 2023, at 05:48 (UTC).

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