Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[5] It is encoded by the gene RND2.[6]
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][7]
This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.
The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[6]
Rnd2 has been shown to interact with:
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3.6.1 |
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3.6.2 |
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3.6.3-4: ATPase |
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3.6.5: GTPase |
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