RhoV (orChporWrch2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. Chp was identified in 1998 as a GTPase interacting with the p21 activated kinase PAK2.[1] RhoV/Chp delineates with RhoU/Wrch a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.[2] RhoV/Chp depends on palmitoylation rather than prenylation for association with plasma and intracellular membranes.[3] In Xenopus embryos, RhoV is encoded by a canonical Wnt response gene and is induced in the developing neural crest at specification. RhoV activity cooperates with the Snai1 (Snail) transcription factor for the subsequent induction of the pro-invasive transcription factors Snai2 (Slug), Sox9orTwist. [4]
Further reading: Rho family of GTPases
| |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3.6.1 |
| ||||||||||||||
3.6.2 |
| ||||||||||||||
3.6.3-4: ATPase |
| ||||||||||||||
3.6.5: GTPase |
|
| |
---|---|
Activity |
|
Regulation |
|
Classification |
|
Kinetics |
|
Types |
|
This EC 3.6 enzyme-related article is a stub. You can help Wikipedia by expanding it. |