Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 References  













Diquafosol






●تۆرکجه
 ●فارسی
 ●Српски / srpski
 ●Srpskohrvatski / српскохрватски
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  

Diquafosol
Names
IUPAC name

O1,O7-Di(5′-deoxyuridin-5′-yl) tetrahydrogen tetraphosphate

Systematic IUPAC name

O1,O7-Bis{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen tetraphosphate

Other names

P1,P4-Bis(5'-uridyl) tetraphosphate; INS-365; Diquafosol tetrasodium

Identifiers

CAS Number
  • 211427-08-6 (tetrasodium salt) checkY

    • 3D model (JSmol)
    ChEMBL
  • ChEMBL221326
    • ChemSpider
  • 130646 (tetrasodium salt)

    • IUPHAR/BPS

    PubChem CID
  • 148196 (tetrasodium salt)
    • UNII
  • X8T9SBH9LL (tetrasodium salt) checkY

    • CompTox Dashboard (EPA)

    • InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1

      Key: NMLMACJWHPHKGR-NCOIDOBVSA-N

    • InChI=1/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1

      Key: NMLMACJWHPHKGR-NCOIDOBVBD

    • O=C1\C=C/N(C(=O)N1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](N\3C(=O)NC(=O)/C=C/3)[C@H](O)[C@@H]4O

    Properties

    Chemical formula

    		 C18H26N4O23P4
    Molar mass 790.306 g·mol−1
    Pharmacology

    ATC code

    		 None

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Infobox references

    Diquafosol (tradename Diquas) is a pharmaceutical drug for the treatment of dry eye disease. It was approved for use in Japan in 2010.[1] It is formulated as a 3% ophthalmic solution of the tetrasodium salt.

    Its mechanism of action involves agonism of the P2Y2 purinogenic receptor.[2]

    References[edit]

    1. ^ "Santen and Inspire Announce Approval of DIQUAS for Dry Eye Treatment in Japan". April 16, 2010.
  • ^ Pendergast, W; Yerxa, BR; Douglass Jg, 3rd; Shaver, SR; Dougherty, RW; Redick, CC; Sims, IF; Rideout, JL (2001). "Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates". Bioorganic & Medicinal Chemistry Letters. 11 (2): 157–60. doi:10.1016/S0960-894X(00)00612-0. PMID 11206448.{{cite journal}}: CS1 maint: numeric names: authors list (link)

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Diquafosol&oldid=1234578762"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Ophthalmology drugs
     ●Nucleotides
     Hidden categories: 
    ●CS1 maint: numeric names: authors list
     ●Chemical articles with multiple compound IDs
     ●Multiple chemicals in an infobox that need indexing
     ●Chemical articles with multiple CAS registry numbers
     ●Chemical articles with multiple PubChem CIDs
     ●Articles without KEGG source
     ●Articles containing unverified chemical infoboxes
     ●Chembox image size set
     ●Articles with short description
     ●Short description matches Wikidata
      


    ●This page was last edited on 15 July 2024, at 02:48 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki