Endonuclease V | |||||||||
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Crystallographic structure of Thermotoga maritima endoV (blue) in complex with DNA (green and orange). The deamidated base is shown in yellow.[1]
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Identifiers | |||||||||
Symbol | ENDOV | ||||||||
Pfam | PF04493 | ||||||||
InterPro | IPR007581 | ||||||||
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Endonuclease V (endoV) is a highly conserved endonuclease enzyme family. The primary function of endoV differs significantly in prokaryotes and eukaryotes, as suggested by studies on the E. coli and human orthologs.
In prokaryotes endoV is primarily a deoxyribonuclease involved in DNA repairofdeoxyinosine introduced into the genomebydeamidationofadenine bases (EC 3.1.21.7).[2] However, it has broad substrate specificity and can also act on other types of DNA lesions[2] as well as on inosine-containing RNA.[3]
In eukaryotes endoV is primarily a ribonuclease and cleaves single-stranded RNA at the 3' position relative to an inosine base, which may be present due to RNA editingbydeaminase enzymes (EC 3.1.26.-).[4] The human endoV localizes to the cytoplasm and nucleoli, suggesting a possible role in processes involving ribosomal RNA.[3] The human gene symbol is ENDOV.
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